Ecology and evolutionary trajectories of morbilliviruses in Neotropical bats

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Jo, Wendy K. ; Moreira-Soto, Andres ; Almeida Campos, Angelica Cristine ; Bentim Goees, Luiz Gustavo ; Mares-Guia, Maria Angelica ; Rasche, Andrea ; Bispo de Filippis, Ana Maria ; Hernandez-Mora, Gabriela ; Nambulli, Sham ; Streicker, Daniel G. ; Duprex, W. Paul ; Drexler, Jan Felix

• Tipo de documento: Artigo Científico
• Fonte: NATURE MICROBIOLOGY; v. 10, n. 6, p. 31-pg., 2025-05-27.

Resumo

Bats are important reservoirs of paramyxoviruses, yet their role in the evolutionary origins of viruses pertaining to the paramyxoviral genus Morbillivirus, such as measles virus, remains unclear. Here, combining field surveys and data mining, we identified six divergent morbilliviruses by investigating wild bats (38/1,629 RT-PCR-positive) and non-human primates (NHP, 13/1,370 RT-PCR-positive) in Brazil and Costa Rica over 14 years. High morbillivirus concentrations of up to 109 RNA copies per g and RNA staining in different organs suggested systemic infection. Of 117 vampire bats, 35.9% had neutralizing antibodies against a primary vampire bat morbillivirus isolate, suggesting frequent non-fatal infections. In vitro assays using bat CD150 for cell entry and partial cross-neutralization of bat-associated morbillivirus by heterologous sera suggested conserved entry and antigenicity. NHP-associated, but not bat-associated morbilliviruses, used human CD150 and nectin-4 cellular receptors, suggesting differential zoonotic potential. Macroevolutionary reconstructions revealed predominance of Neotropical bat hosts during morbilliviral diversification, including bat-associated host shifts into Mexican pigs and Brazilian NHPs. These data argue for increased surveillance, experimental risk assessments and intervention strategies to mitigate risks of reservoir-bound morbilliviruses shifting hosts. (AU)

• Processo FAPESP: 14/15090-8 - Monitoramento de vírus influenza em morcegos da região tropical e sub tropical do Brasil
• Beneficiário: Angélica Cristine Góes de Almeida Campos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/20744-5 - Paramixovírus de morcegos no Brasil: caracterização molecular, análise evolutiva e de risco à saúde humana e animal
• Beneficiário: Angélica Cristine Góes de Almeida Campos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado