| Texto completo | |
| Autor(es): |
Duran, Nelson
;
Favaro, Wagner J.
;
Castro, Symone C. de
;
Nakazato, Gerson
;
Castro, Guillermo R.
;
Justo, Giselle Z.
;
Tasic, Ljubica
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the Brazilian Chemical Society; v. 36, n. 10, p. 17-pg., 2025-01-01. |
| Resumo | |
Violacein is one of the very attractive biomolecules and a purple pigment known worldwide because of its pharmacological potential as an antibacterial, antifungal, antiviral, anticancer, antiulcerogenic, trypanocide, and immunomodulatory drug. It is mainly produced through biosynthesis using bacterial strains, recombinant strategies, and synthetic biology. There are also a few total organic synthesis proposals. Nevertheless, low yields, difficulties with bacterial cell growth inhibition, and laborious biosynthetic and total synthesis pathways have impaired the upscaling of violacein fabrication. Another major challenge is the purification strategy that still has not been solved despite efforts and improvements, a reason for the very high costs, impairing the violaceinwide applications even as a drug. The current review aims to address different aspects of violacein, such as its production, purification, biological activities, and toxicity, helping to enhance its viability for biotechnological applications. (AU) | |
| Processo FAPESP: | 18/10052-1 - Novas Abordagens Terapêuticas para o Câncer de Bexiga Não-Músculo Invasivo (CBNMI): Uso Intravesical do Modificador de Resposta Biológica OncoTherad e Sua Associação com o Plasma Rico em Plaquetas (PRP) |
| Beneficiário: | Wagner José Fávaro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |