| Texto completo | |
| Autor(es): |
Dias Fonseca, Adriany
;
Ribeiro, Victor Pena
;
Arruda, Caroline
;
Portapilla, Gisele Bulhoes
;
de Albuquerque, Sergio
;
Bastos, Jairo Kenupp
;
Furtado, Niege Aracari Jacometti Cardoso
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURAL PRODUCT RESEARCH; v. N/A, p. 8-pg., 2025-08-07. |
| Resumo | |
Brazilian green propolis has recognised commercial and medicinal value, with baccharin identified as one of its major bioactive compounds, exhibiting cytotoxicity against breast and prostate cancer cell lines. However, the activity of its metabolites remains poorly understood. This study investigated the biotransformation of baccharin by intestinal bacteria and filamentous fungi that mimic human metabolism. Cultures were incubated with 600 mu L of baccharin (0.1 mg/mL in ethanol), yielding three metabolites. Escherichia coli, Lactobacillus acidophilus, L. johnsonii, and Saccharomyces boulardii hydrolysed baccharin to drupanin, with up to 79.1% conversion by E. coli after 48 h. Cunninghamella elegans and Aspergillus alliaceus catalysed hydrolysis, hydroxylation, and beta-oxidation. Baccharin and its metabolites, evaluated at concentrations ranging from 1.56 to 200 mu M, showed low or no cytotoxicity in normal (fibroblasts, MCF-10A, PNT-2) and tumour (MCF-7, MDA-MB-231, DU-145, PC-3) cell lines. Cisplatin and doxorubicin showed IC50 values of 4.6-85.9 mu M and <0.78-5.99 <mu>M, respectively, across cell lines. (AU) | |
| Processo FAPESP: | 18/03476-0 - Biotransformações da bacarina da própolis verde utilizando fungos filamentosos e bactérias da microbiota intestinal |
| Beneficiário: | Adriany Dias Fonseca |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 24/05555-5 - Novas formulações de extratos de própolis verde: estudos comparativos de bioacessibilidade, permeabilidade intestinal e biotransformação de seus constituintes bioativos. |
| Beneficiário: | Niege Araçari Jacometti Cardoso Furtado |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |