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| Autor(es): Mostrar menos - |
Batista dos Santos, Juliana de Melo
;
Furtado, Guilherme Eustaquio
;
Correa-Sousa, Eviton
;
Brandao-Rangel, Maysa Alves Rodrigues
;
Oliveira-Junior, Manoel Carneiro
;
da Silva Cardoso, Katielle Rodrigues
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de Souza, Mariana Alvarez
;
Rodrigues, Francisco
;
Coelho, Patricia
;
Franco de Oliveira, Luis Vicente
;
Lacerda Bachi, Andre Luis
;
Sampaio Jorge, Luciana Malosa
;
Lopes-Martins, Patricia Sardinha Leonardo
;
Albertini, Regiane
;
Vieira, Rodolfo P.
Número total de Autores: 15
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| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. N/A, p. 17-pg., 2025-07-26. |
| Resumo | |
The incidence of metabolic syndrome (MetS) is rising rapidly, particularly among older adults, and is associated with comorbidities that impair respiratory and immune functions. Physical exercise has proven effective in mitigating the adverse effects of both aging and MetS. However, evidence on the impact of high-intensity resistance training (HIRT) on the respiratory and immune systems in older adults with MetS remains limited. This study aimed to evaluate the effects of HIRT on respiratory function, skeletal muscle strength, and immune modulation in older adults with MetS, highlighting its potential as a complementary therapeutic approach. A total of 43 older adults with MetS were enrolled and divided into two groups: a HIRT intervention group (n = 23; mean age 66.71 +/- 4.98 years) and a non-exercising control group (n = 20; mean age 66.91 +/- 5.26 years). The HIRT protocol involved twice-weekly sessions (10 total) over 5 weeks, performed at 80-90% of one-repetition maximum. Results showed that HIRT significantly improved lung mechanics (R5Hz, R20Hz, Z5Hz, X5Hz), peripheral muscle strength, and both maximal expiratory and inspiratory pressures. Furthermore, HIRT increased anti-inflammatory and anti-fibrotic cytokines in sputum (klotho, IL-10, adiponectin) and serum (klotho, relaxin-1, relaxin-3, IL-10), while reducing pro-inflammatory cytokines in sputum (IL-6, TNF-alpha) and serum (IL-1ra, IL-6, TNF-alpha, leptin). A decrease in total leukocyte, neutrophil, lymphocyte, and monocyte counts was also observed. In conclusion, HIRT effectively mitigates the effects of MetS on respiratory, muscular, and immune functions in older adults and may be recommended as a complementary strategy for managing MetS in this population. (AU) | |
| Processo FAPESP: | 19/11008-9 - O papel do treinamento físico nas respostas pró e anti-fibróticas pulmonares de indivíduos asmáticos |
| Beneficiário: | Renilson Moraes Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/05739-0 - Papel das cininas nos efeitos anti-inflamatórios do treinamento aeróbio em modelo experimental de Asma |
| Beneficiário: | Maysa Alves Rodrigues Brandão Rangel |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos |
| Beneficiário: | Rodolfo de Paula Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |