LATE SIDE EFFECTS OF RADIOACTIVE IODINE ON SALIVARY GLAND FUNCTION IN PATIENTS WITH THYROID CANCER

Autor(es)

Almeida, Juliana Pereira ^[1] ; Sanabria, Alvaro Enrique ^[2] ; Pereira Lima, Eduardo Nobrega ^[3] ; Kowalski, Luiz Paulo ^[1]

Afiliação do(s) autor(es)

^[1] Hosp AC Camargo Fund Antonio Prudente, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

^[2] Univ La Sabana, Fdn Clin Abood Shaio, Dept Surg, Bogota - Colombia

^[3] Hosp AC Camargo Fund Antonio Prudente, Dept Nucl Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 33, n. 5, p. 686-690, MAY 2011.
• Citações Web of Science: 53

Resumo

Background. The purpose of this study was to assess the late side effects of radioiodine therapy (RIT) on salivary gland function. One hundred eighty two patients were evaluated. Methods. Assessment of salivary gland function was performed with salivary gland scintigraphy (SGS), sialometry, and subjective open questions to determine common side effects of RIT on salivary gland function. Results. RIT had a strong association with decreased elimination counts by SGS. Patient age was the only variable associated with sialometry; age and the use of xerostomic drugs were strongly associated with decreased mean values of salivary flow. Dysphagia was strongly associated with RIT. Using multiple logistic regression analysis, age was determined to be an important factor associated with salivary gland dysfunction, and RIT was associated with impairment of saliva excretion. Conclusion. These results show that patients subjected to RIT have more difficulty in draining saliva, mainly from the parotid glands, which is associated with clinical dysphagia in this subset of patients. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 686-690, 2011 (AU)

• Processo FAPESP: 06/50061-2 - Avaliação da função das glândulas salivares em pacientes submetidos à iodoterapia adjuvante para tratamento de carcinomas bem-diferenciados de tireóide
• Beneficiário: Luiz Paulo Kowalski
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/60474-0 - Avaliação da função das glândulas salivares em pacientes submetidos à iodoterapia adjuvante para tratamento de carcinomas bem diferenciados de tireoide
• Beneficiário: Juliana Pereira Almeida
• Modalidade de apoio: Bolsas no Brasil - Doutorado