The Unfolded Protein Response: How Protein Folding Became a Restrictive Aspect for Innate Immunity and B Lymphocytes

Autor(es)

Costa, C. Z. F. ^[1] ; da Rosa, S. E. A. ^[1] ; de Camargo, M. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Scandinavian Journal of Immunology; v. 73, n. 5, p. 436-448, MAY 2011.
• Citações Web of Science: 8

Resumo

Chaperone production is an essential step for proper folding of certain proteins. Accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER) lumen triggers a signalling pathway named unfolded protein response (UPR). Upon activation, the UPR pathway augments transcription of ER chaperones increasing protein folding, decreases protein translation to ameliorate the ER overload, increases protein degradation, and activates the apoptotic programme if all previous measures fail. In this review, we will cover the chaperones involved in folding of proteins related to the immune response, followed by an overview of the UPR pathway. Lastly, we will discuss data from this last decade that demonstrate how the improper activation of the UPR pathway has been uncovered as a mechanism responsible for failure to mount a proper immune response, both innate and adaptive. (AU)

• Processo FAPESP: 09/06529-8 - Regulação da homeostasia do ER em linfócitos B na imunodeficiencia comum variável
• Beneficiário: Susana Elaine Alves da Rosa
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/51326-8 - Regulação da homeostasia do Er em linfócitos B na imunodeficiência comum variável
• Beneficiário: Maristela Martins de Camargo
• Modalidade de apoio: Auxílio à Pesquisa - Regular