| Texto completo | |
| Autor(es): |
Ventura, Priscilla Dantas de Souza
;
de Souza, Daniel Vitor
;
Aguiar, Anna Caroline C.
;
Carvalho, Carolina P. F.
;
Ribeiro, Daniel A.
;
Nagaoka, Marcia R.
;
Gazarini, Marcos L.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; v. 119, p. 8-pg., 2025-09-01. |
| Resumo | |
The genus Plasmodium is responsible for malaria infection and promoting an accumulation of hemozoin followed by the generation of oxidizing species in the liver that is involved in hepatic damage. In this context, we performed the histopathological analysis in the mice liver infected with Plasmodium chabaudi treated orally with the antimalarial chloroquine, captopril (ACE I inhibitor), losartan (AT1 receptor blocker). In hematoxylin and eosinstained liver sections, histopathological changes, such as sinusoid congestion, leukocyte infiltration, hemozoin deposition, portal tract inflammation, and metanuclear analysis were evaluated. The histopathological analysis shows a beneficial effect of chloroquine treatment alone or in combination with vasodilator treatments, reducing the score for each tissue change. Our data show that Plasmodium chabaudi infection compromises some hepatic histopathological parameters, and interestingly the treatment with vasodilators improved some of these alterations. Particularly, captopril reduces cytotoxicity induced by malaria infection in mouse liver cells. (AU) | |
| Processo FAPESP: | 17/00896-5 - Citoproteção hepática: da fibrose a isquemia e reperfusão |
| Beneficiário: | Márcia Regina Nagaoka |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/19708-0 - Identificação de novos compostos antimaláricos: uma estratégia multidisciplinar visando a busca por classes ativas contra novos alvos moleculares e diferentes estágios de vida do Plasmodium spp |
| Beneficiário: | Anna Caroline Campos Aguiar |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 09/54598-9 - Proteólise intracelular em parasitas da malária: caracterização e inibição de proteases em um novo ensaio para o screening de drogas antimaláricas |
| Beneficiário: | Marcos Leoni Gazarini Dutra |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |