Autor(es)

Moreira dos Santos, Murilo ; Santos Moure, Henrique ; Ferreira, Marcelo Jose Pena ; Ishida, Kelly

• Tipo de documento: Artigo Científico
• Fonte: VIRULENCE; v. 16, n. 1, p. 10-pg., 2025-12-31.

Resumo

Candidozyma auris is associated with nosocomial outbreaks presenting high resistance rates to antifungal. Since its emergence in 2009, research has been carried out on the underlying quorum sensing molecules (QSMs), such as farnesol (Far) and tyrosol (Tyr). Our main goal was to quantify Far and Tyr in C. auris biofilms and assess their role in virulence using a Galleria mellonella larvae model. Among the tested strains, the most virulent CBS 12766 produced the highest QSMs levels, whereas the least virulent strain CBS 10913 produced the lowest. Notably, C. auris exhibited higher QSM production per biofilm dry weight and the virulence profile was associated with greater QSM levels. In addition, the virulent reference strain Candida albicans SC5314 produced largest amounts of QSMs and higher biofilm total biomass. In conclusion, we reported for the first time the production of Far and Tyr in C. auris biofilms, suggesting a potential association with the virulence of this emerging pathogen. (AU)

• Processo FAPESP: 20/16554-9 - Asteraceae e fungos endofíticos: caracterização de metabólitos secundários e atividades biológicas
• Beneficiário: Marcelo José Pena Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/12190-0 - Moléculas com potencial antifúngico sobre Candida e Cryptococcus e investigação dos mecanismos de ação: inibição e morte celular
• Beneficiário: Kelly Ishida
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/08516-5 - Investigação de moléculas com potencial antifúngico sobre Candida auris e Candida tropicalis: efeitos antifúngicos, morfofisiológicos e moleculares
• Beneficiário: Murilo Moreira dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/01279-5 - Investigação de novos alvos e moléculas antifúngicas sobre Candida spp. e Cryptococcus spp.
• Beneficiário: Kelly Ishida
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 23/12793-7 - Resposta adaptativa de Candida auris a anidulafungina e compostos naturais com potencial anti-Candida auris
• Beneficiário: Henrique Santos Moure
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto