| Texto completo | |
| Autor(es): |
Marchiori, Marcelo Fiori
;
Chellegatti, Maria Angelica dos Santos Cunha
;
Camargo, Joao Victor Silveira
;
Braz, Vania Santos
;
Ambrosio, Sergio R.
;
Bastos, Jairo Kenupp
;
Silva, Guilherme Martins
;
Furtado, Niege Aracari Jacometti Cardoso
;
Campo, Vanessa Leiria
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Tetrahedron Letters; v. 171, p. 5-pg., 2025-11-15. |
| Resumo | |
The increasing number of fungal infections and resistance to available drugs represent a serious threat to public health. In this context, the aim of this work was the synthesis of a novel series of polyalthic acid-1,2,3-triazolearylsulfonamide derivatives by Cu(I)-catalysed azide-alkyne cycloaddition reactions ("click chemistry"), along with the evaluation of their antifungal properties against three Candida species. The best activities were observed for compounds 4, 6 and 7 against Candida albicans (MIC/MFC 6.25 to 12.5 mu g/ml), and for compounds 9 and 3 against Candida krusei (MIC/ MFC 12.5 to 50 mu g/ml). These findings highlight the potential of polyalthic acid derivatives as viable candidates for the development of new triazole antifungal agents. (AU) | |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |