Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women

Autor(es)

Campos, A. F. ^[1] ; Tengan, F. M. ^[1] ; Silva, S. A. A. ^[2] ; Levi, J. E. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Infect Dis, Sch Med, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Trop Med, Virol Lab, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF STD & AIDS; v. 22, n. 4, p. 209-213, APR 2011.
• Citações Web of Science: 4

Resumo

This study was undertaken to evaluate the prevalence of GB virus C (GBV-C) viraemia and anti-E2 antibody, and to assess the effect of co-infection with GBV-C and HIV during a 10-year follow-up of a cohort of 248 HIV-infected women. Laboratory variables (mean and median CD4 counts, and HIV and GBV-C viral loads) and clinical parameters were investigated. At baseline, 115 women had past exposure to GBV-C: 57 (23%) were GBV-C RNA positive and 58 (23%) were anti-E2 positive. There was no statistical difference between the groups (GBV-C RNA + /anti-E2 -, GBV-C RNA - /anti-E2 + and GBV-C RNA - /anti-E2 -) regarding baseline CD4 counts or HIV viral loads (P = 0.360 and 0.713, respectively). Relative risk of death for the GBV-C RNA + /anti-E2 - group was 63% lower than that for the GBV-C RNA - /anti-E2 - group. Multivariate analysis demonstrated that only HIV loads >= 100,000 copies/mL and AIDS-defining illness during follow-up were associated with shorter survival after AIDS development. It is likely that antiretroviral therapy (ART) use in our cohort blurred a putative protective effect related to the presence of GBV-C RNA. (AU)

• Processo FAPESP: 05/01072-9 - A influência da infecção pelo GB virus com virus da hepatite G (HGV) na evolução da doença pelo HIV em mulheres
• Beneficiário: José Eduardo Levi
• Modalidade de apoio: Auxílio à Pesquisa - Regular