| Texto completo | |
| Autor(es): |
Xavier, Marilia Brasil
;
Fontes, Lucas Dos Santos
;
Do Nascimento, Mariana Garcia Borges
;
Dos Passos, Simone Rodrigues
;
Xavier, Debora Pinheiro
;
Alcantara, Larissa Dos Santos
;
De Brito, Elza Baia
;
Gomes, Claudia Maria De Castro
;
Corbett, Carlos Eduardo Pereira
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MICROORGANISMS; v. 13, n. 10, p. 15-pg., 2025-09-27. |
| Resumo | |
Leprosy remains a significant public health issue, particularly due to its neuropathic consequences, which affect sensory, motor, and autonomic functions, leading to severe disabilities. HIV/AIDS, another major public health concern, overlaps geographically with leprosy and is also associated with peripheral neuropathies, complicating the management of co-infected patients. Understanding how Nerve Growth Factor (NGF) is regulated in leprosy and HIV-leprosy co-infection may contribute to immunomodulatory treatments and neuroimmune response control. A cross-sectional study evaluated NGF tissue expression using immunohistochemistry in 47 HIV/leprosy co-infected patients and 61 leprosy-only patients. The co-infected group had a higher incidence of neuritis (40.4%) and a prevalence of exclusively reversal reactions. However, the occurrence of neuritis was not associated with higher expression of NGF in the tissue. Leprosy reactions were more prevalent in non-co-infected patients with multibacillary forms (50%). Multibacillary forms in both groups of patients showed higher cellular expression of NGF, with a greater tendency for higher NGF expression in non-co-infected multibacillary patients (p = 0.0021), suggesting impairment in the immune response involved in the tissue expression of neurotrophins in the co-infected group. Overall, co-infection with HIV did not influence the increase in NGF in the lesions of leprosy patients compared with patients with leprosy alone. (AU) | |
| Processo FAPESP: | 14/50315-0 - Leishmanioses na América Latina: uma perspectiva avançada sobre fatores imunopatogenéticos da infecção cutânea e visceral, imunomoduladores da saliva de vetores flebotomíneos e exo-antígenos imunogênicos de Leishmania (L.) infantum chagasi candidatos à vacina |
| Beneficiário: | Marcia Dalastra Laurenti |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |