| Texto completo | |
| Autor(es): |
Pereira, Daniela A.
;
de Castro, Ricardo N. F.
;
Palei, Ana C.
;
Cavalli, Ricardo C.
;
Sandrim, Valeria C.
;
Luizon, Marcelo R.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACOGENOMICS; v. N/A, p. 10-pg., 2025-10-13. |
| Resumo | |
AimsWe compared plasma adiponectin levels between patients with preeclampsia (PE) classified as responsive and nonresponsive to antihypertensive therapy; Moreover, we examined whether ADIPOQ SNPs rs17300539, rs266729,rs2241766, and rs1501299 and their haplotypes are associated with responsiveness to antihypertensive therapy, and whether they affect plasma adiponectin levels in 215 pregnant women with PE.Patients & methodsGenotypes for ADIPOQ SNPs were determined using TaqMan allelic discrimination assays, and circulating adiponectin concentrations were measured by ELISA.ResultsPatients with PE classified as nonresponsive to antihypertensive therapy showed higher plasma adiponectin levels than responsive patients. The TG genotype of the rs2241766 SNP was more frequent in responsive patients with PE when compared to nonresponsive patients. Nonresponsive patients with PE carrying specific genotypes of the ADIPOQ SNPs rs17300539 (GG or GA+AA), rs266729 (CC), rs2241766(TT), and rs1501299 (GT+TT), respectively, as well as the 'G,C,T,G' and 'G,C,T,T' haplotypes showed higher plasma adiponectin levels than responsive patients with PE carrying the same genotypes/haplotypes.ConclusionsNonresponsive patients with PE showed higher plasma adiponectin levels than responsive patients, the TG genotype of the rs2241766 SNP was more frequent in the responsive patients with PE when compared to nonresponsive patients. Genotypes of rs17300539, rs266729, rs2241766, and rs1501299 SNPs and haplotypes may affect adiponectin levels in patients with PE classified as nonresponsive to antihypertensive therapy. (AU) | |
| Processo FAPESP: | 19/07230-8 - Arginase em pré-eclâmpsia: estudo de polimorfismos genéticos, fatores circulantes e ensaios in vitro |
| Beneficiário: | Valeria Cristina Sandrim |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/12010-7 - Disfunção endotelial em doenças hipertensivas da gestação |
| Beneficiário: | Valeria Cristina Sandrim |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |