Oral Administration of Aloe vera and Honey Reduces Walker Tumour Growth by Decreasing Cell Proliferation and Increasing Apoptosis in Tumour Tissue

Autor(es)

Tomasin, Rebeka ^[1] ; Cintra Gomes-Marcondes, Maria Cristina ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Inst Biol, Dept Anat Cell Biol & Physiol & Biophys, Lab Nutr & Canc, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 25, n. 4, p. 619-623, APR 2011.
• Citações Web of Science: 23

Resumo

Cancer is diagnosed in approximately 11 million people and is responsible for almost 8 million deaths worldwide every year. Research in cancer control has shown the importance of co-adjuvant therapies. Aloe vera may reduce tumour mass and metastasis rates, while honey may inhibit tumour growth. This study verified the influence of Aloe vera and honey on tumour growth and in the apoptosis process by assessing tumour size, the cell proliferation rate (Ki67-LI) and Bax/Bcl-2 expression at 7, 14 and 20 days after Walker 256 carcinoma implant in Wistar rats distributed into two groups: the WA group - tumour-bearing rats that received a gavage with a 670 mu L/kg dose of Aloe vera and honey solution daily, and the CW group - tumour-bearing rats which received only a 0.9% NaCl solution. The effect of Aloe vera and honey against tumour growth was observed through a decrease in relative weight (%) and Ki67-LI in tumours from the WA group compared with those from the CW group. The Bax/Bcl-2 ratio increased in tumours from the WA group at all tested timepoints. These data suggest Aloe vera and honey can modulate tumour growth by reducing cell proliferation and increasing apoptosis susceptibility. Copyright (C) 2010 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 06/06007-3 - Estudo dos mecanismos bioquímicos e moleculares da caquexia: avaliação dos efeitos do Fator Walker (FW) e da leucina sobre células C2C12 e Vero, em cultura
• Beneficiário: Maria Cristina Cintra Gomes Marcondes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/05788-4 - Efeitos preventivos e terapêuticos do homogeneizado de Aloe vera e mel sobre o crescimento e atividade celular do carcinossarcoma de Walker 256 in vivo e in vitro
• Beneficiário: Rebeka Tomasin
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/04645-2 - Estudo do metabolismo protéico em ratos implantados com carcinossarcoma de Walker 256, submetidos a atividade física associada a suplementação nutricional de leucina
• Beneficiário: Maria Cristina Cintra Gomes Marcondes
• Modalidade de apoio: Auxílio à Pesquisa - Regular