| Texto completo | |
| Autor(es): Mostrar menos - |
Eulalio, Denise
;
Figueiredo, Mariana Pires
;
Silva, Simone S.
;
Rodrigues, Luisa C.
;
Fernandes, Emanuel M.
;
Martins, Albino
;
Franco, Albina
;
da Costa, Diana Soares
;
Landers, Richard
;
Leroux, Fabrice
;
Taviot-Gueho, Christine
;
de Faria, Dalva Lucia Araujo
;
Reis, Rui L.
;
Constantino, Vera Regina Leopoldo
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | APPLIED CLAY SCIENCE; v. 281, p. 15-pg., 2026-03-01. |
| Resumo | |
Zinc ions and N-acetylcysteine (NAC) are bioactive agents with key physiological roles. When associated with biomacromolecules such as silk fibroin (SF), they offer a promising pathway for advanced biomedical applications. This study reports the synthesis of layered zinc hydroxide (LZH) intercalated with NAC as well as the development of LZH-NAC/SF scaffolds. The synthesis of LZH-NAC was conducted using a constant-pH method, and experimental parameters were controlled to obtain a monophasic LZH. Comprehensive structural, spectroscopic, textural, and thermal characterisation confirmed the successful intercalation of NAC into the LZH. The employed methodology enabled the production of an LZH-NAC nanomaterial with an encapsulation efficiency of approximately 80 % by mass and a loading capacity of around 30 %. To evaluate its biomedical potential, LZH-NAC/SF 3D composite scaffolds were prepared by dispersing LZH-NAC in SF solution, followed by freezing and freeze-drying. The average pore sizes observed in the scaffolds ranged from 75 to 87 mu m, and the swelling capacity was approximately 1700 % after incubation in phosphate-buffered saline (pH 7.4). Cytocompatibility assays revealed that LZH-NAC/SF scaffolds supported cell viability at a zinc concentration of 0.189 mg/mL, similar to that of the SF and NAC/SF scaffolds. These results underscore the potential of LZH-NAC/SF scaffolds as multifunctional biomaterials for the controlled delivery of therapeutic agents, with significant implications for tissue engineering and drug delivery systems. (AU) | |
| Processo FAPESP: | 16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release |
| Beneficiário: | Vera Regina Leopoldo Constantino |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/50869-6 - INCT 2014: em Eletrônica Orgânica INEO |
| Beneficiário: | Roberto Mendonça Faria |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |