| Texto completo | |
| Autor(es): |
Batista, Angela Giovana
;
Mendonca, Monique Culturato P.
;
Soares, Edilene Siqueira
;
da Silva-Maia, Juliana Kelly
;
Dionisio, Ana Paula
;
Sartori, Cesar R.
;
da Cruz-Hofling, Maria Alice
;
Marostica Junior, Mario Roberto
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Functional Foods; v. 65, p. 10-pg., 2020-02-01. |
| Resumo | |
In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) and investigated proofs of peripheral insulin resistance, hippocampal AKT-GSK3-beta-tau activation, learning/memory performance, and brain frontal lobe oxidative stress. The intake of HS did not prevent weight gain but promoted peripheral insulin sensitivity, improved AKT signaling in the hippocampus, which prevented the activation of GSK3-beta and lowered tau phosphorylation induced in HF. The results from the Morris water maze cognitive test were consistent with the lower tau-phosphorylation, once the HS group showed lower latency in the acquisition phase and more times crossing the target quadrant when compared with HF. The HS diet improved brain antioxidant enzyme activities. Overall, the intervention with S. malaccense fruit to mice was effective in minimizing cognitive deficit caused by HF consumption and in preventing risk markers associated with Alzheimers disease without reducing weight gain in mice. (AU) | |
| Processo FAPESP: | 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras |
| Beneficiário: | Glaucia Maria Pastore |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos |
| Beneficiário: | Mário Roberto Maróstica Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |