Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking

Autor(es)

Tomita, Luciana Y. ^[1] ; Roteli-Martins, Cecilia M. ^[2] ; Villa, Luisa L. ^[3] ; Franco, Eduardo L. ^[4] ; Cardoso, Marly A. ^[1] ; Team, BRINCA Study

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-01246904 Sao Paulo - Brazil

^[2] Hosp Leonor Mendes de Barros, BR-03015000 Sao Paulo - Brazil

^[3] Ludwig Inst Canc Res, BR-01323903 Sao Paulo - Brazil

^[4] McGill Univ, Div Canc Epidemiol, Montreal, PQ H2W 1S6 - Canada

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 105, n. 6, p. 928-937, MAR 28 2011.
• Citações Web of Science: 11

Resumo

Smoking has been positively and fruit and vegetable intake has been negatively associated with cervical cancer, the second most common cancer among women worldwide. However, a lower consumption of fruits and reduced serum carotenoids have been observed among smokers. It is not known whether the smoking effect on the risk of cervical neoplasia is modified by a low intake of fruits and vegetables. The present study examined the combined effects of tobacco smoking and diet using a validated FFQ and serum carotenoid and tocopherol levels on cervical intraepithelial neoplasia grade 3 (CIN3) risk in a hospital-based case-control study conducted in Sao Paulo, Brazil, between 2003 and 2005. The sample comprised 231 incident, histologically confirmed cases of CIN3 and 453 controls. A low intake (<= 39 g) of dark-green and deep-yellow vegetables and fruits without tobacco smoking had a lesser effect on CIN3 (OR 1.14; 95% CI 0.49, 2.65) than among smokers with higher intake (>= 40 g; OR 1.83; 95% CI 0.73, 4.62) after adjusting for confounders. The OR for the joint exposure of tobacco smoking and low intake of vegetables and fruits was greater (3.86; 95% CI 1.74, 8.57; P for trend < 0.001) compared with non-smokers with higher intake after adjusting for confounding variables and human papillomavirus status. Similar results were observed for total fruit, serum total carotene (including beta-, alpha-and gamma-carotene) and tocopherols. These findings suggest that the effect of nutritional factors on CIN3 is modified by smoking. (AU)

• Processo FAPESP: 02/11184-0 - Consumo alimentar e níveis séricos de micronutrientes: associação com lesões neoplásicas do colo uterino
• Beneficiário: Luciana Yuki Tomita
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 03/03013-4 - Consumo alimentar e níveis séricos de micronutrientes: associação com lesões neoplásicas do colo uterino
• Beneficiário: Marly Augusto Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular