| Texto completo | |
| Autor(es): |
Castelletto, Valeria
;
Edwards-Gayle, Charlotte J. C.
;
Hamley, Ian W.
;
Barrett, Glyn
;
Seitsonen, Jani
;
Ruokolainen, Janne
;
de Mello, Lucas Rodrigues
;
da Silva, Emerson Rodrigo
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMICAL COMMUNICATIONS; v. 56, n. 4, p. 4-pg., 2020-01-14. |
| Resumo | |
Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3 '-5 ')-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR. (AU) | |
| Processo FAPESP: | 16/24409-3 - Peptídeos Penetrantes de Células para Transporte de DNA plasmídial e microRNA: da Estrutura Nanoscópica a Entrega de Genes. |
| Beneficiário: | Emerson Rodrigo da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |