| Texto completo | |
| Autor(es): |
Vieira, Ana Julia
;
Beserra, Fernando Pereira
;
Prata, Gabriel Bacil
;
Martinez, Emanuel Ricardo Monteiro
;
Nobrega, Rafael Henrique
;
Barbisan, Luis Fernando
;
Pellizzon, Claudia Helena
;
Rozza, Ariane Leite
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHARMACEUTICS; v. 18, n. 1, p. 15-pg., 2026-01-19. |
| Resumo | |
Background/Objectives: Diabetes mellitus impairs skin wound healing by promoting a chronic inflammatory response and increased oxidative stress. This study aimed to investigate the healing potential of menthol in skin wounds of diabetic rats. Methods: A single dose of streptozotocin (50 mg/kg, i.p.) induced type 1 diabetes mellitus in male Wistar rats. After nine days, a skin wound was made on the rats' back and treated with vehicle, insulin-based cream (0.5 U/g), or menthol-based cream (0.5%) for 14 days. After the euthanasia, the wound area was destined for assays of anti-inflammatory and antioxidant activity, protein expression levels by Western blotting, measurement of MPO activity, and quantitative mRNA expression. Nitrite levels were measured in blood plasma. Results: The group treated with menthol-based cream decreased the wound area by 94%. Also, menthol reduced the levels of TNF-alpha and IL-6 and increased IL-10 levels, besides stimulating the activity of antioxidant enzymes SOD, GPx, and GR, and enhancement in GSH and nitrite levels. Menthol downregulated the expression of Nf kappa b and upregulated the Il10 and Ki67 gene expression and the eNOS protein expression. Conclusions: Topically applied menthol accelerated the skin wound healing in diabetic rats through anti-inflammatory and antioxidant activities and increased cell proliferation, supporting its potential as a therapeutic strategy for diabetic wound management. (AU) | |
| Processo FAPESP: | 16/13307-5 - Mecanismos fisiológicos envolvidos na cicatrização cutânea após tratamento com mentol em ratos diabéticos e não-diabéticos |
| Beneficiário: | Ariane Leite Rozza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/03230-2 - Efeito do mentol na cicatrização de feridas cutâneas em ratos diabéticos |
| Beneficiário: | Amanda Capeletti Vendrami |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |