Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration

Autor(es)

Machado, Rafael Ventura ^[1] ; Mauricio, Adriana Fogagnolo ^[1] ; Tiemi Taniguti, Ana Paula ^[1] ; Ferretti, Renato ^[1] ; Santo Neto, Humberto ^[1] ; Marques, Maria Julia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Dept Anat Biol Celular Fisiol & Biofis, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroimmunology; v. 232, n. 1-2, p. 145-150, MAR 2011.
• Citações Web of Science: 24

Resumo

In dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-alpha) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-alpha. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-alpha, and support further investigations of EPA as a potential therapy for dystrophinopathies. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular