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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration

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Autor(es):
Machado, Rafael Ventura [1] ; Mauricio, Adriana Fogagnolo [1] ; Tiemi Taniguti, Ana Paula [1] ; Ferretti, Renato [1] ; Santo Neto, Humberto [1] ; Marques, Maria Julia [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Anat Biol Celular Fisiol & Biofis, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Neuroimmunology; v. 232, n. 1-2, p. 145-150, MAR 2011.
Citações Web of Science: 24
Resumo

In dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-alpha) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-alpha. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-alpha, and support further investigations of EPA as a potential therapy for dystrophinopathies. (C) 2010 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica
Beneficiário:Maria Julia Marques
Linha de fomento: Auxílio à Pesquisa - Regular