| Texto completo | |
| Autor(es): Mostrar menos - |
Fermiano, Joao Thiago Aragao
;
Ali, Sher
;
Ullah, Sana
;
Rezende, Vanessa Theodoro
;
Rosim, Roice Eliana
;
Tonin, Fernando Gustavo
;
Ferri, Walusa Assad Goncalves
;
Marcolin, Alessandra Cristina
;
Ramalho, Leandra Naira Zambelli
;
de Oliveira, Carlos Augusto Fernandes
;
Ramalho, Fernando Silva
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TOXINS; v. 17, n. 10, p. 18-pg., 2025-10-21. |
| Resumo | |
This study aimed to conduct a first evaluation of maternal exposure to mycotoxins during pregnancy in Brazil through quantification of biomarkers in liver and serum samples from stillborn and neonates autopsied in the Clinical Hospital of Ribeir & atilde;o Preto, state of S & atilde;o Paulo. Liver tissue (n = 43) and serum (n = 38) samples were collected from 43 patients and analyzed for biomarkers of aflatoxins (AFs), ochratoxin A (OTA), fumonisins (FBs), zearalenone (ZEN), deoxynivalenol (DON), T-2 and HT-2 toxins by ultra-performance liquid chromatography coupled to tandem mass spectrometry. In total, 9 samples of liver (20.9%) and 33 serum (86.8%) had quantifiable levels of mycotoxins. In liver samples, aflatoxin M1 (AFM1) was quantified in two samples (median level: 0.38 ng/g), while four samples had OTA residues (median: 0.31 ng/g) and one contained ZEN (3.6 ng/g). Compared with liver tissue, serum samples had higher occurrence rates of mycotoxins, particularly AFM1, OTA and ZEN. Nineteen serum samples (50%) contained 2-4 types of mycotoxins, indicating an effective transplacental transfer of major mycotoxins during pregnancy. Median levels of AFM1, OTA, FB1, ZEN, DON, T-2 and HT-2 toxins in serum samples were 0.48, 3.39, 30.6, 10.53, 5.71, 2.85 and 10.84 ng/mL, respectively. The most frequent cause of death was extreme prematurity (33% of cases), followed by preterm premature rupture of membranes (16% of cases) and morphological abnormalities (42% of cases). Results of this trial suggest potential associations between dietary mycotoxins and congenital anomalies. Further research should clarify the transplacental transfer of mycotoxins and their association with toxic effects during human prenatal development. (AU) | |
| Processo FAPESP: | 22/03952-1 - Avaliação da exposição de crianças às micotoxinas através da dieta em Ribeirão Preto/SP |
| Beneficiário: | Sher Ali |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/21603-1 - Abordagens de biomarcadores para avaliar a exposição precoce a múltiplas micotoxinas na dieta |
| Beneficiário: | Carlos Augusto Fernandes de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 23/05989-2 - Avaliação da co-ocorrência de micotoxinas em alimentos infantis em Pirassununga e Ribeirão Preto/SP |
| Beneficiário: | Sana Ullah |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |