| Texto completo | |
| Autor(es): |
Baptista, Sophia N.
;
Faria, Alessandra V. S.
;
Ferreira-Halder, Carmen, V
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER; v. 1880, n. 6, p. 15-pg., 2025-11-14. |
| Resumo | |
Melanoma, an aggressive skin cancer, poses significant global health challenges due to its increasing incidence and high metastatic potential. While traditionally focused on genetic mutations, recent research highlights the critical role of cellular organelle dysfunction and intricate inter-organelle communication in both keratinocytes and melanocytes during melanoma pathogenesis. This systematic review explores how alterations within key organelles, including mitochondria, endoplasmic reticulum (ER), Golgi apparatus, lysosomes, peroxisomes, and lamellar bodies. reprogram cellular behavior and contribute to disease progression. We detail how mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels in keratinocytes can prime the microenvironment for melanocyte transformation. Lysosomes and peroxisomes, vital for degradation, lipid metabolism, and redox balance, when compromised, impair cellular differentiation and oxidative stress management, fostering a protumorigenic state. The ER and ribosomes, crucial for protein synthesis and quality control, are frequently impacted by environmental stressors like UV radiation, leading to adaptive or detrimental cellular responses. Furthermore, the proper function of lamellar bodies, essential for skin barrier integrity, is intrinsically linked to Golgi and lysosomal health, with disruptions influencing melanoma dissemination. Understanding the complex interplay and dysregulation of these organelles offers a multifaceted perspective on melanoma, moving beyond isolated cellular events to reveal systemic imbalances. This review underscores the potential for developing novel strategies that target specific organelle pathways, aiming to restore cellular homeostasis and effectively combat tumor progression. (AU) | |
| Processo FAPESP: | 25/12311-8 - Biohacking de Melanoma por Riboflavina Micelar: Validação em Pele Bioimpressa |
| Beneficiário: | Sophia Nora Baptista |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 24/22874-7 - SKIN RESCUE - One World, One Health: investigação do elo entre a transdução de sinal em células da pele e a exposição a materiais particulados e estresse térmico |
| Beneficiário: | Alessandra Valéria de Sousa Faria |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 25/00313-6 - Destruição do melanoma por formulação micelar para aplicação tópica: validação em pele multicelular bioimpressa |
| Beneficiário: | Carmen Veríssima Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |