| Texto completo | |
| Autor(es): |
Batista, Lais Duarte
;
Rogero, Marcelo Macedo
;
Sarti, Flavia Mori
;
Costa, Marcela Larissa
;
Franca, Jaqueline Lopes Pereira
;
Valentini Neto, Joao
;
Fisberg, Regina Mara
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | METABOLITES; v. 15, n. 12, p. 18-pg., 2025-11-21. |
| Resumo | |
Background: Polymorphisms in the FADS1 and FADS2 genes influence fatty acid metabolism. However, evidence of gene-diet interactions in population-based studies from Brazil remains limited. The objective of this study was to examine associations between FADS1-FADS2 single-nucleotide polymorphisms (SNPs) and erythrocyte fatty acid composition and serum lipid concentrations, as well as to explore potential gene-diet interactions. Methods: Data were analyzed from 294 adults (20-93 years) enrolled in the 2015 ISA-Nutrition study. Erythrocyte fatty acid composition and serum lipids were measured using standard enzymatic methods. Dietary intake was assessed by 24 h recalls, and participants were classified into tertiles according to fatty acid intake. Five SNPs were genotyped; FADS1 rs174546 and FADS2 rs174570 were prioritized based on linkage disequilibrium. Associations and interactions were assessed using generalized linear models, adjusting for confounders. Results: Carriers of the minor alleles for rs174546 and rs174570 had significantly lower erythrocyte levels of long-chain polyunsaturated fatty acids, particularly along the omega-6 pathway, suggesting reduced desaturase activity. The rs174546 TT genotype was associated with higher total, very-low-density lipoprotein cholesterol (VLDL), and non-high-density lipoprotein (non-HDL) cholesterolconcentrations. Higher dietary intakes of docosahexaenoic acid (DHA) or a higher linoleic acid to alpha-linolenic acid ratio(LA/ALA ratio) among these carriers were linked to lower serum lipid levels, indicating gene-diet interactions that attenuate adverse genotype effects. In addition, rs174570 TT carriers showed elevated VLDL concentrations, with a significant dietary interaction observed with the LA/ALA ratio. Conclusions: FADS1 and FADS2 polymorphisms influence fatty acid metabolism and interact with diet to shape lipid profiles. These findings highlight the importance of considering gene-diet interactions in cardiometabolic risk. (AU) | |
| Processo FAPESP: | 17/05125-7 - Estilo de vida, marcadores bioquímicos e genéticos como fatores de risco cardiometabólico: inquérito de saúde na cidade de São Paulo |
| Beneficiário: | Regina Mara Fisberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/11755-1 - Identificação e comparação de pontos de corte para o índice ômega-3 relacionado com fatores de risco cardiometabólico em adultos brasileiros e porto-riquenhos |
| Beneficiário: | Lais Duarte Batista |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |