Improvements in Insulin Sensitivity and Muscle Blood Flow in Aerobic-Trained Overweight-Obese Hypertensive Patients Are Not Associated With Ambulatory Blood Pressure

Autor(es)

Waib, Paulo H. ^[1] ; Goncalves, Maria I. ^[1] ; Barrile, Silvia R. ^[1]

Afiliação do(s) autor(es)

^[1] Higher Educ Bur Sao Paulo State, Marilia Sch Med, Hypertens Res Ctr, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL HYPERTENSION; v. 13, n. 2, p. 89-96, FEB 2011.
• Citações Web of Science: 7

Resumo

To verify whether there are relationships between vascular and hormonal responses to aerobic training in hypertensive persons, sedentary hypertensive patients were randomized to an aerobic training or a callisthenic exercise group. The patients' 24-hour blood pressure, arterial compliance, forearm blood flow, and hormonal profile were evaluated at baseline and after 3-month training protocols. Mean maximal oxygen consumption (VO(2)max) increased by 8% in the aerobic group (P <.001), while no change was observed in the control group. There was a decrease in insulin resistance (homeostatic model assessment of insulin resistance, P=.039) and plasma cortisol (P=.006) in the aerobic group only, that also demonstrated an increase in forearm blood flow (P <.001) after training. No relationship was observed between change in blood pressure or change in body mass and other parameters. Aerobic training can promote a decrease in cardiovascular risk in hypertensive adults by improving vascular function and insulin resistance, despite no changes in ambulatory blood pressure after a 3-month intervention. J Clin Hypertens (Greenwich). 2011;13:89-96. (C)2010 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 98/15931-8 - Inter-relações entre os perfis metabólico-hormonais da hipertensão essencial e as respostas às terapias farmacológica e não farmacológica
• Beneficiário: Paulo Henrique Waib
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores