Enzymatic Activity, Sensitivity to Antifungal Drugs and Baccharis dracunculifolia Essential Oil by Candida Strains Isolated from the Oral Cavities of Breastfeeding Infants and in Their Mothers' Mouths and Nipples

Autor(es)

Pereira, Cristiane Aparecida ^[1] ; Borges Pereira da Costa, Anna Carolina ^[1] ; Silva Machado, Ana Karina ^[1] ; Beltrame Junior, Miltom ^[2] ; Amorin Costa Zoellner, Maria Stella ^[3] ; Junqueira, Juliana Campos ; Cardoso Jorge, Antonio Olavo ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sao Jose dos Campos Dent Sch, Lab Microbiol & Immunol, Dept Biosci & Oral Diag, BR-12245000 Sao Paulo - Brazil

^[2] UNIVAP, Inst Res & Dev, Sao Paulo - Brazil

^[3] Taubate Univ UNITAU, Biosci Inst, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Mycopathologia; v. 171, n. 2, p. 103-109, FEB 2011.
• Citações Web of Science: 14

Resumo

Candida strains can cause oral candidosis, as well as nipples candidosis and lead to premature weaning or yeast transmission. The aim of this study was to evaluate 51 Candida isolates obtained from the oral cavities of infants during breastfeeding and mothers' oral cavities and nipples, their enzymatic activity and their sensitivity to amphotericin B, fluconazole and Baccharis dracunculifolia essential oil. Among the studied strains, 96.1% produced phospholipase and 78.4% produced proteinase. The antifungal resistance was only observed among isolates of C. albicans, for which three strains showed a resistant activity to fluconazole and one showed a resistant activity to amphotericin B. All strains were sensitive to B. dracunculifolia essential oil with MIC between 0.2 and 6.25 mg/ml. It was concluded that most of the strains showed significant enzymatic activity and were sensitive to amphotericin B and fluconazole. B. dracunculifolia essential oil inhibited the growth of all strains, including the ones resistant to commercial antifungal agents. (AU)

• Processo FAPESP: 10/00879-4 - MICRORGANISMOS OPORTUNISTAS EM LESÕES DE ESTOMATITE PROTÉTICA E INFLUÊNCIA DA TERAPIA FOTODINÂMICA NOS FATORES DE VIRULÊNCIA DE Candida spp.
• Beneficiário: Cristiane Aparecida Pereira Correia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/12005-1 - Avaliação da terapia fotodinâmica em Candida albicans in vitro e in vivo
• Beneficiário: Anna Carolina Borges Pereira da Costa
• Modalidade de apoio: Bolsas no Brasil - Mestrado