The Relationship between Plasma alpha-Tocopherol Concentration and Vitamin E Intake in Patients with Type 2 Diabetes Mellitus

Autor(es)

Illison, Vanessa K. ^[1] ; Rondo, Patricia H. C. ^[1] ; de Oliveira, Andreia M. ^[1] ; D'Abronzo, Francisco H. ^[2] ; Campos, Katia F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

^[2] Jundiai Med Sch, Dept Internal Med, Jundiai, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH; v. 81, n. 1, p. 12-20, JAN 2011.
• Citações Web of Science: 8

Resumo

Type 2 diabetes mellitus (DM2) predisposes to an increased production of free radicals and a probable reduction in plasma antioxidants, including vitamin E. This cross-sectional study investigated the relationship between plasma alpha-tocopherol concentration and vitamin E intake in 58 Brazilians with DM2. Plasma alpha-tocopherol was determined by high-performance liquid chromatography. The intake of vitamin E-rich foods was assessed by a food frequency questionnaire. Total cholesterol and fractions were measured by colorimetric enzymatic methods. Data on demographic and socioeconomic factors, life habits, and anthropometry were obtained by a questionnaire and physical examination. The association between plasma alpha-tocopherol and vitamin E intake was assessed by multiple linear regression analysis. The following variables were included in the regression model: alpha-tocopherol, vitamin E intake, total cholesterol and fractions, body mass index, waist circumference, gender, age, education, occupation, income, smoking, alcohol intake, and blood pressure. There was no association between alpha-tocopherol and vitamin E intake, but there were significant associations between alpha-tocopherol and total cholesterol (p < 0.001) and waist circumference (p = 0.003). There were 36.2 % diabetics with low alpha-tocopherol concentrations (< 12 mu mol/L) and 32.7 % with a low alpha-tocopherol/total cholesterol ratio (< 2.2). Further large, epidemiological, longitudinal studies, including measurements of gamma-tocopherol in blood, should be conducted to confirm our results. (AU)

• Processo FAPESP: 04/04108-1 - O impacto da suplementacao com acido alfa-lipoico e alfa-tocoferol no controle da resistencia a insulina e outros componentes da sindrome metabolica em pacientes com diabetes mellitus tipo 2.
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular