Conjugated linoleic acid supplementation: lipid content and hepatic histology in healthy Wistar rats

Autor(es)

Santos-Zago, Lilia Ferreira ^[1] ; Botelho, Adriana Prais ^[1] ; de Oliveira, Admar Costa ^[1] ; Marostica Junior, Mario Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Fac Engn Alimentos, Dept Alimentos & Nutr, Lab Lipides, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FOOD SCIENCE AND TECHNOLOGY; v. 31, n. 1, p. 141-146, JAN-MAR 2011.
• Citações Web of Science: 2

Resumo

This work aimed to evaluate the effects of the consumption of two commercial conjugated linoleic acid (CLA) mixtures on lipid content and liver histology of healthy rats. The investigation was carried out using thirty rats divided into three groups: C (control), AE (AdvantEdge (R) CLA), and CO (CLA One (R)). The concentration of CLA was 2% of feed consumption, and the animals were supplemented daily for 42 days. The total lipid content of the liver was determined, and the histology of the organ was examined by Transmission Electronic Microscopy. The results of total liver lipid contents did not exhibit significant differences between the groups. With regard to hepatic histology, it was observed that although fat globules were visibly present in higher numbers and bigger size in the CLA groups, the organ histology was considered normal since both cytoplasm and organelles showed integrity. It was concluded that even though liver microscopic images indicated the presence of fat globules in the liver, from a statistical point of view, the supplementation for 42 days did not bring about lipid accumulation, nor did it alter hepatic histology. (AU)

• Processo FAPESP: 03/07648-4 - A suplementacao de acido linoleico conjugado e o perfil lipidico, composicao corporal, peroxidacao lipidica em ratos.
• Beneficiário: Admar Costa de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular