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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conjugated linoleic acid supplementation: lipid content and hepatic histology in healthy Wistar rats

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Author(s):
Santos-Zago, Lilia Ferreira [1] ; Botelho, Adriana Prais [1] ; de Oliveira, Admar Costa [1] ; Marostica Junior, Mario Roberto [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Fac Engn Alimentos, Dept Alimentos & Nutr, Lab Lipides, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: FOOD SCIENCE AND TECHNOLOGY; v. 31, n. 1, p. 141-146, JAN-MAR 2011.
Web of Science Citations: 2
Abstract

This work aimed to evaluate the effects of the consumption of two commercial conjugated linoleic acid (CLA) mixtures on lipid content and liver histology of healthy rats. The investigation was carried out using thirty rats divided into three groups: C (control), AE (AdvantEdge (R) CLA), and CO (CLA One (R)). The concentration of CLA was 2% of feed consumption, and the animals were supplemented daily for 42 days. The total lipid content of the liver was determined, and the histology of the organ was examined by Transmission Electronic Microscopy. The results of total liver lipid contents did not exhibit significant differences between the groups. With regard to hepatic histology, it was observed that although fat globules were visibly present in higher numbers and bigger size in the CLA groups, the organ histology was considered normal since both cytoplasm and organelles showed integrity. It was concluded that even though liver microscopic images indicated the presence of fat globules in the liver, from a statistical point of view, the supplementation for 42 days did not bring about lipid accumulation, nor did it alter hepatic histology. (AU)