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Evaluation chemistry, biochemistry and cell of conjugated isomers of polyunsaturated fatty acid on biochemical parameters in processes oxidative and inflammatory

Grant number: 13/24490-7
Support Opportunities:Regular Research Grants
Duration: March 01, 2014 - February 29, 2016
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Jorge Mancini Filho
Grantee:Jorge Mancini Filho
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The conjugated fatty acids have commercial and scientific appeal on reduction of body fat and increased lean body mass, although they are also considered as antioxidants and anti-inflammatory. Punicic acid (C18:3-9c,11t,13c) and ±-eleostearic (C18:3-9c,11t,13t) are conjugated ±-linolenic acid (C18:3-9c,12c,15c) isomers, known as CLNAs, present in high concentrations in pomegranate seed oil and bitter gourd seed oil, respectively. Despite being structurally very similar to conjugated linoleic acids (CLAs) and ±-linolenic acid (LNA), which increases the interest in these isomers, is not sure if the CLNAs have benefits similar to those of CLAs and/or LNA. In general, researches on the effects of conjugated fatty acids in the body are still limited and inconclusive, sometimes showing different functions between different isomers studied. In addition, studies show that CLNAs are metabolized and incorporated in the form of CLAs in animal tissues. Therefore, Additional studies are needed to understand the effects of this incorporation that may be altering the composition of lipids in cell membranes, interfere in the metabolism of these fatty acids for the production of eicosanoids and inflammatory cytokines and its molecular mechanisms in tissues and cells. It is proposed in this project to evaluate the effect of isomers of conjugated fatty acids (conjugated linoleic acid, punicic acid and ±-eleostearic acid) on parameters involving lipid metabolism, oxidative stress and inflammation to the tissue level (rats - serum, liver and adipose tissue) and cellular (Raw 264.7, adipocyte 3T3 and Caco-2). (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
YOSHIME, LUCIANA TEDESCO; PEREIRA DE MELO, ILLANA LOUISE; GASPAROTTO SATTLER, JOSE AUGUSTO; TORRES, ROSANGELA PAVAN; MANCINI-FILHO, JORGE. Bioactive compounds and the antioxidant capacities of seed oils from pomegranate (Punica granatum L.) and bitter gourd (Momordica charantia L.). FOOD SCIENCE AND TECHNOLOGY, v. 39, n. 2, p. 571-580, . (13/24490-7)
PEREIRA DE MELO, ILLANA LOUISE; TEIXEIRA DE CARVALHO, ELIANE BONIFACIO; DE OLIVEIRA E SILVA, ANA MARA; YOSHIME, LUCIANA TEDESCO; GASPAROTTO SATTLER, JOSE AUGUSTO; PAVAN, ROSANGELA TORRES; MANCINI-FILHO, JORGE. Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.). FOOD SCIENCE AND TECHNOLOGY, v. 36, n. 1, p. 8-pg., . (13/24490-7, 09/51891-7)
PEREIRA DE MELO, ILLANA LOUISE; DE OLIVEIRA E SILVA, ANA MARA; TEIXEIRA DE CARVALHO, ELIANE BONIFACIO; YOSHIME, LUCIANA TEDESCO; GASPAROTTO SATTLER, JOSE AUGUSTO; MANCINI-FILHO, JORGE. Incorporation and effects of punicic acid on muscle and adipose tissues of rats. LIPIDS IN HEALTH AND DISEASE, v. 15, . (09/51891-7, 13/24490-7)
PEREIRA DE MELO, ILLANA LOUISE; TEIXEIRA DE CARVALHO, ELIANE BONIFACIO; DE OLIVEIRA E SILVA, ANA MARA; YOSHIME, LUCIANA TEDESCO; GASPAROTTO SATTLER, JOSE AUGUSTO; PAVAN, ROSANGELA TORRES; MANCINI-FILHO, JORGE. Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.). FOOD SCIENCE AND TECHNOLOGY, v. 36, n. 1, p. 132-139, . (09/51891-7, 13/24490-7)

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