| Texto completo | |
| Autor(es): |
Dal Bo, Alexandre G.
[1, 2]
;
Soldi, Valdir
[1]
;
Giacomelli, Fernando C.
[3]
;
Jean, Bruno
[2]
;
Pignot-Paintrand, Isabelle
[2]
;
Borsali, Redouane
[2]
;
Fort, Sebastien
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil
[2] Univ Grenoble 1, Ctr Rech Macromol Vegetales CERMAV CNRS, F-38041 Grenoble 9 - France
[3] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SOFT MATTER; v. 7, n. 7, p. 3453-3461, 2011. |
| Citações Web of Science: | 14 |
| Resumo | |
Biocompatible low-polydispersity micelles designed for lectin targeting have been prepared by spontaneous self-assembly in water of macromolecular glycosylated amphiphiles. Propargyl-beta-lactoside and N-acetyl-beta-D-glucosaminide were conjugated by copper-catalyzed Huisgen cycloaddition to azide-terminated PEG 900 stearate. Upon dissolution in water, the resulting amphiphiles immediately self-assemble into highly regular micelles having a mean diameter of 10 nm. Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and Small-Angle X-ray Scattering (SAXS) were used to investigate the structure of the self-assembled saccharidic amphiphiles micelles. The presence of the carbohydrate epitopes on the surface of the micelles and their bioavailability for lectin targeting were also demonstrated by light scattering measurements. Specific interaction of the GlcNac and Lac residues with Wheat Germ Agglutinin (WGA) and Peanut Agglutinin (PNA) respectively, unveils potential applications of such carbohydrate-derived surfactants as simple and site-specific vectorization systems for drug delivery. (AU) | |
| Processo FAPESP: | 10/06348-0 - Desenvolvimento de sistemas poliméricos supramoleculares versáteis para aplicação na liberação controlada de agentes antitumorais |
| Beneficiário: | Fernando Carlos Giacomelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |