State of the art etch-and-rinse adhesives

Autor(es)

Pashley, David H. ^[1] ; Tay, Franklin R. ^[2] ; Breschi, Lorenzo ^{[3, 4]} ; Tjaderhane, Leo ^{[5, 6]} ; Carvalho, Ricardo M. ^[7] ; Carrilho, Marcela ^{[8, 9]} ; Tezvergil-Mutluay, Arzu ^[10]

Afiliação do(s) autor(es)

^[1] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 - USA

^[2] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 - USA

^[3] IGM CNR, Unit Bologna IOR, Bologna - Italy

^[4] Univ Trieste, Dept Biomed, Trieste - Italy

^[5] Univ Oulu, Inst Dent, Oulu - Finland

^[6] Oulu Univ Hosp, Oulu - Finland

^[7] Univ Sao Paulo, Dept Prosthodont, Bauru Sch Dent, Bauru - Brazil

^[8] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba - Brazil

^[9] Univ Bandeirante Sao Paulo, GEO UNIBAN, Hlth Inst, Sao Paulo - Brazil

^[10] Univ Turku, Inst Dent, Dept Prosthet Dent, Turku - Finland

• Tipo de documento: Artigo Científico
• Fonte: Dental Materials; v. 27, n. 1, p. 1-16, JAN 2011.
• Citações Web of Science: 389

Resumo

Objectives: The aim of this study was to explore the therapeutic opportunities of each step of 3-step etch-and-rinse adhesives. Methods: Etch-and-rinse adhesive systems are the oldest of the multi-generation evolution of resin bonding systems. In the 3-step version, they involve acid-etching, priming and application of a separate adhesive. Each step can accomplish multiple goals. Acid-etching, using 32-37% phosphoric acid (pH 0.1-0.4) not only simultaneously etches enamel and dentin, but the low pH kills many residual bacteria. Results: Some etchants include anti-microbial compounds such as benzalkonium chloride that also inhibits matrix metalloproteinases (MMPs) in dentin. Primers are usually water and HEMA-rich solutions that ensure complete expansion of the collagen fibril meshwork and wet the collagen with hydrophilic monomers. However, water alone can re-expand dried dentin and can also serve as a vehicle for protease inhibitors or protein cross-linking agents that may increase the durability of resin-dentin bonds. In the future, ethanol or other water-free solvents may serve as dehydrating primers that may also contain antibacterial quaternary ammonium methacrylates to inhibit dentin MMPs and increase the durability of resin-dentin bonds. The complete evaporation of solvents is nearly impossible. Significance: Manufacturers may need to optimize solvent concentrations. Solvent-free adhesives can seal resin-dentin interfaces with hydrophobic resins that may also contain fluoride and antimicrobial compounds. Etch-and-rinse adhesives produce higher resin-dentin bonds that are more durable than most 1 and 2-step adhesives. Incorporation of protease inhibitors in etchants and/or cross-linking agents in primers may increase the durability of resin-dentin bonds. The therapeutic potential of etch-and-rinse adhesives has yet to be fully exploited. (C) 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 07/54618-4 - Avaliação da atividade de colagenases na degradação da dentina humana tratada por procedimentos restauradores adesivos
• Beneficiário: Marcela Rocha de Oliveira Carrilho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores