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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

State of the art etch-and-rinse adhesives

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Author(s):
Pashley, David H. [1] ; Tay, Franklin R. [2] ; Breschi, Lorenzo [3, 4] ; Tjaderhane, Leo [5, 6] ; Carvalho, Ricardo M. [7] ; Carrilho, Marcela [8, 9] ; Tezvergil-Mutluay, Arzu [10]
Total Authors: 7
Affiliation:
[1] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 - USA
[2] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 - USA
[3] IGM CNR, Unit Bologna IOR, Bologna - Italy
[4] Univ Trieste, Dept Biomed, Trieste - Italy
[5] Univ Oulu, Inst Dent, Oulu - Finland
[6] Oulu Univ Hosp, Oulu - Finland
[7] Univ Sao Paulo, Dept Prosthodont, Bauru Sch Dent, Bauru - Brazil
[8] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba - Brazil
[9] Univ Bandeirante Sao Paulo, GEO UNIBAN, Hlth Inst, Sao Paulo - Brazil
[10] Univ Turku, Inst Dent, Dept Prosthet Dent, Turku - Finland
Total Affiliations: 10
Document type: Journal article
Source: Dental Materials; v. 27, n. 1, p. 1-16, JAN 2011.
Web of Science Citations: 389
Abstract

Objectives: The aim of this study was to explore the therapeutic opportunities of each step of 3-step etch-and-rinse adhesives. Methods: Etch-and-rinse adhesive systems are the oldest of the multi-generation evolution of resin bonding systems. In the 3-step version, they involve acid-etching, priming and application of a separate adhesive. Each step can accomplish multiple goals. Acid-etching, using 32-37% phosphoric acid (pH 0.1-0.4) not only simultaneously etches enamel and dentin, but the low pH kills many residual bacteria. Results: Some etchants include anti-microbial compounds such as benzalkonium chloride that also inhibits matrix metalloproteinases (MMPs) in dentin. Primers are usually water and HEMA-rich solutions that ensure complete expansion of the collagen fibril meshwork and wet the collagen with hydrophilic monomers. However, water alone can re-expand dried dentin and can also serve as a vehicle for protease inhibitors or protein cross-linking agents that may increase the durability of resin-dentin bonds. In the future, ethanol or other water-free solvents may serve as dehydrating primers that may also contain antibacterial quaternary ammonium methacrylates to inhibit dentin MMPs and increase the durability of resin-dentin bonds. The complete evaporation of solvents is nearly impossible. Significance: Manufacturers may need to optimize solvent concentrations. Solvent-free adhesives can seal resin-dentin interfaces with hydrophobic resins that may also contain fluoride and antimicrobial compounds. Etch-and-rinse adhesives produce higher resin-dentin bonds that are more durable than most 1 and 2-step adhesives. Incorporation of protease inhibitors in etchants and/or cross-linking agents in primers may increase the durability of resin-dentin bonds. The therapeutic potential of etch-and-rinse adhesives has yet to be fully exploited. (C) 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. (AU)