Three-year follow-up study of respiratory and systemic manifestations of chronic obstructive pulmonary disease

Autor(es)

Ferrari, R. ^[1] ; Tanni, S. E. ^[1] ; Faganello, M. M. ^[2] ; Caram, L. M. O. ^[1] ; Lucheta, P. A. ^[1] ; Godoy, I. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP, Dept Clin Med, Fac Med Botucatu, Disciplina Pneumol, BR-18618970 Botucatu, SP - Brazil

^[2] UNISALESIANO, Dept Fisioterapia, Lins, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 44, n. 1, p. 46-52, JAN 2011.
• Citações Web of Science: 12

Resumo

Few studies show patient outcomes over time in chronic obstructive pulmonary disease (COPD). In the present study, we monitored forced expiratory volume in the first second (FEV(1)) and other manifestations of the disease over 3 years in 133 COPD patients (69% males, age = 65 +/- 9 years, FEV(1) = 59 +/- 25%) evaluated at baseline. During follow-up, 15 patients (11%) died and 23 (17%) dropped out. Measurements for 95 (72%) COPD patients alive after 3 years were analyzed. FEV(1), body mass index (BMI), 6-min walking distance (6MWD), Medical Research Council scale (MRC), Saint George's Respiratory Questionnaire (SGRQ), Charlson Comorbidity index, and BODE index were obtained at baseline and after 3 years. At baseline, 17 patients (18%) presented mild, 39% moderate, 19% severe, and 24% very severe COPD. Predicted FEV(1) % and BMI did not change over the period (P > 0.05). FEV(1) in liters {[}1.25 (0.96-1.72) vs 1.26 (0.88-1.60) L; P < 0.001], 6MWD (438 +/- 86 vs 412 +/- 100 m; P < 0.001), MRC {[}1 (1-2) vs 2 (1-3); P = 0.002], Charlson index {[}3 (3-4) vs 4 (3-5); P = 0.009], BODE index (2.2 +/- 1.8 vs 2.6 +/- 2.3; P = 0.008), and total SGRQ (42 +/- 19 vs 44 +/- 19%; P = 0.041) worsened after 3 years compared to baseline measurements. These data show that COPD patients deteriorated during the 3-year follow-up despite the fact that they had only minor modifications in airway obstruction and body composition. They support the need for comprehensive patient assessment to better identify disease progression. (AU)

• Processo FAPESP: 04/00517-4 - Papel dos mediadores inflamatórios e da vitamina A nos diferentes estádios e nas manifestações clínicas da doença pulmonar obstrutiva crônica
• Beneficiário: Irma de Godoy
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/52667-0 - Evolução dos marcadores diagnósticos e prognósticos de pacientes com DPOC no período de três anos
• Beneficiário: Renata Ferrari
• Modalidade de apoio: Bolsas no Brasil - Mestrado