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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cytokine levels in sites of chronic periodontitis of poorly controlled and well-controlled type 2 diabetic subjects

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Autor(es):
Santos, Vanessa Renata ; Ribeiro, Fernanda Vieira ; Lima, Jadson Almeida ; Napimoga, Marcelo Henrique [1, 2] ; Bastos, Marta Ferreira ; Duarte, Poliana Mendes [3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Uberaba, Mol Biol Lab, Uberaba, MG - Brazil
[2] Ctr Res Sao Leopoldo Mand, Sao Paulo - Brazil
[3] Univ Guarulhos, Ctr Posgrad & Pesquisa, Dept Periodontol, Dent Res Div, BR-07023070 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 37, n. 12, p. 1049-1058, DEC 2010.
Citações Web of Science: 41
Resumo

P>Aim This study compared the levels of tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-4, IL-17 and IL-23 in the gingival crevicular fluid (GCF) from well-controlled and poorly controlled type 2 diabetic subjects with chronic periodontitis, before and after periodontal therapy. Material and Methods Eighteen well-controlled (glycated haemoglobin levels <= 8%) and 20 poorly controlled (glycated haemoglobin levels > 8%) diabetic subjects were enrolled in this study. All subjects were submitted to non-surgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed before, 3 and 6 months post-therapy. Total amounts and concentrations of TNF-alpha, IFN-gamma, IL-4, IL-17 and IL-23 in the GCF were analysed by enzyme-linked immunosorbent assay (ELISA). Results The levels of IL-17 were higher in poorly than in well-controlled subjects (p < 0.05), whereas the levels of IFN-gamma were increased in well- compared with poorly controlled subjects at all experimental groups (p < 0.05). In addition, IL-4 levels were lower in well- than poorly controlled diabetic subjects at baseline (p < 0.05). There were no differences between groups for TNF-alpha and IL-23 at any time points (p > 0.05). Conclusion These results indicate a predominance of pro-inflammatory T-helper type 1 (Th1)- or Th17-cytokines in sites of chronic periodontitis from type 2 diabetic subjects, according to their glycaemic control. (AU)

Processo FAPESP: 08/09687-0 - Tratamento periodontal em indivíduos diabéticos compensados e não-compensados portadores de Diabetes Mellitus: avaliação clínica, glicêmica e dos níveis de citocinas e fatores de reabsorção óssea
Beneficiário:Poliana Mendes Duarte
Linha de fomento: Auxílio à Pesquisa - Regular