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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytokine levels in sites of chronic periodontitis of poorly controlled and well-controlled type 2 diabetic subjects

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Author(s):
Santos, Vanessa Renata ; Ribeiro, Fernanda Vieira ; Lima, Jadson Almeida ; Napimoga, Marcelo Henrique [1, 2] ; Bastos, Marta Ferreira ; Duarte, Poliana Mendes [3]
Total Authors: 6
Affiliation:
[1] Univ Uberaba, Mol Biol Lab, Uberaba, MG - Brazil
[2] Ctr Res Sao Leopoldo Mand, Sao Paulo - Brazil
[3] Univ Guarulhos, Ctr Posgrad & Pesquisa, Dept Periodontol, Dent Res Div, BR-07023070 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 37, n. 12, p. 1049-1058, DEC 2010.
Web of Science Citations: 41
Abstract

P>Aim This study compared the levels of tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-4, IL-17 and IL-23 in the gingival crevicular fluid (GCF) from well-controlled and poorly controlled type 2 diabetic subjects with chronic periodontitis, before and after periodontal therapy. Material and Methods Eighteen well-controlled (glycated haemoglobin levels <= 8%) and 20 poorly controlled (glycated haemoglobin levels > 8%) diabetic subjects were enrolled in this study. All subjects were submitted to non-surgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed before, 3 and 6 months post-therapy. Total amounts and concentrations of TNF-alpha, IFN-gamma, IL-4, IL-17 and IL-23 in the GCF were analysed by enzyme-linked immunosorbent assay (ELISA). Results The levels of IL-17 were higher in poorly than in well-controlled subjects (p < 0.05), whereas the levels of IFN-gamma were increased in well- compared with poorly controlled subjects at all experimental groups (p < 0.05). In addition, IL-4 levels were lower in well- than poorly controlled diabetic subjects at baseline (p < 0.05). There were no differences between groups for TNF-alpha and IL-23 at any time points (p > 0.05). Conclusion These results indicate a predominance of pro-inflammatory T-helper type 1 (Th1)- or Th17-cytokines in sites of chronic periodontitis from type 2 diabetic subjects, according to their glycaemic control. (AU)

FAPESP's process: 08/09687-0 - Periodontal treatment in controlled and uncontrolled Diabetic subjects: clinical, glycemic and cytokine and bone resorption related factors evaluations
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants