Smart hollow microspheres of chondroitin sulfate conjugates and magnetite nanoparticles for magnetic vector

Autor(es)

Guilherme, Marcos R. ^[1] ; Reis, Adriano V. ^[1] ; Alves, Bruno R. V. ^[2] ; Kunita, Marcos H. ^[3] ; Rubira, Adley F. ^[3] ; Tambourgi, Elias B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Sistemas Quim & Informat DESQ, Fac Engn Quim, BR-13081970 Campinas, SP - Brazil

^[2] Univ Estadual Maringa, Dept Farm & Farmacol, Lab Farmacotecnol, BR-87020900 Maringa, Parana - Brazil

^[3] Univ Estadual Maringa, Dept Quim, Grp Mat Polimer & Compositos, BR-87020900 Maringa, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Colloid and Interface Science; v. 352, n. 1, p. 107-113, DEC 1 2010.
• Citações Web of Science: 11

Resumo

Smart hollow microspheres composed of vinyled-chondroitin sulfate conjugates (CS pi) and magnetite nanoparticles were obtained by the intermediate of a multiple emulsion in absence of a surfactant, attributable to stabilizing properties of the CS. It was formed an oil-water multiple emulsion in which the CS played a role as an anionic stabilizer for magnetite nanoparticles via complexation. Iron oxides were bonded to the microspheres by the formation of a complex of Fe(3+) ions on the crystalline phase with oxygen atoms at the carboxyl groups without their magnetic properties being affected. The average crystal size of embedded magnetite nanoparticles was approximately 16.5 nm, indicative of a good dispersion in microspheres. Furthermore, the introduction of iron oxides resulted in microspheres with a higher diameter and a narrower particle size distribution. (C) 2010 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 06/50952-4 - Síntese de hidrogéis superabsorventes à base de pectina para liberação prolongada de água e insumos agrícolas
• Beneficiário: Marcos Rogério Guilherme
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado