Impact of Epstein-Barr virus in the clinical evolution of patients with classical Hodgkin's Lymphoma in Brazil

Autor(es)

Souza, Eni M. ^[1] ; Baiocchi, Otavio C. G. ^[1] ; Zanichelli, Maria A. ^[2] ; Alves, Antonio C. ^[1] ; Assis, Marianne G. ^[1] ; Eiras, Daniel P. ^[1] ; Dobo, Cristine ^[1] ; Oliveira, Jose S. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Disciplina Hematol & Hemoterapia, Hematol & Transfus Serv, BR-04023060 Sao Paulo - Brazil

^[2] Brigadeiro State Hosp, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HEMATOLOGICAL ONCOLOGY; v. 28, n. 3, p. 137-141, SEP 2010.
• Citações Web of Science: 5

Resumo

Introduction: Classical Hodgkin's Lymphoma (cHL) has been frequently associated with Epstein Barr virus (EBV), which can be found in a latent pattern in Reed-Sternberg (RS) cells. However, the impact of the presence of EBV in RS cells and its prognosis are still controversial. We analysed the presence of EBV in RS cells and its influence in the clinical evolution of patients with cHL treated in two public hospitals in the city of Sao Paulo, Brazil. Materials and Methods: We selected 97 patients with cHL from 1994 to 2004. Patients were only included in this study if they had (1) >18 years, (2) negative HIV serology, (3) undergone similar chemotherapy protocols, (4) paraffin blocks available with enough material for systematic review and histological reclassification and for detection of EBV in RS cells by in situ hybridization and immunohistochemistry and (5) clinical, epidemiological and laboratorial parameters available after a thorough chart review. Results: EBV was identified in 52.5% of the cases. Mixed cellularity (MC) subtype was more common in EBV-related tumours (25.5%) (p =0.005). There was no difference on age, gender, stage and the presence of B symptoms between the two groups. The presence of EBV did not influence event free survival (EFS) (p =0.38) or overall survival (OS) (p = 0.80) with a median follow-up of 80 months. Conclusion: We demonstrate that the prevalence of EBV-related cHL in this Brazilian population is 52.5% and, that, the presence of EBV does not change the clinical evolution and OS of patients treated with similar chemotherapy protocols. Copyright (C) 2010 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 02/09994-4 - O papel das moléculas de adesão na mobilização de células progenitoras hematopoéticas CD34+ em pacientes com mieloma múltiplo e linfoma não-Hodgkin
• Beneficiário: José Salvador Rodrigues de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 02/10290-1 - Avaliação das alterações causadas ao microambiente medular pelas drogas quimioterápicas, fatores de crescimento e doença de base em pacientes com linfoma não-Hodgkin de alto grau de malignidade e mieloma múltiplo, no período de mobilização de células CD34+
• Beneficiário: José Salvador Rodrigues de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular