Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome

Autor(es)

Castelar, L. ^[1] ; Silva, M. M. ^[1] ; Castelli, E. C. ^[2] ; Deghaide, N. H. S. ^[2] ; Mendes-Junior, C. T. ^[3] ; Machado, A. A. ^[2] ; Donadi, E. A. ^[2] ; Fernandes, A. P. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Coll Nursing Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TISSUE ANTIGENS; v. 76, n. 2, p. 126-130, AUG 2010.
• Citações Web of Science: 13

Resumo

Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions -607(C/A) and -137(C/G) in the promoter region of the interleukin-18 (IL-18) gene and at position +874(T/A) of the interferon-gamma (IFN-gamma) gene are related to the expression of these cytokines. To examine whether IL-18 and IFN-gamma polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)-infected patients presenting LS, 79 HIV-infected without LS, and 133 healthy controls. The -607A allele, -607AA genotype, and -137G/-607A and -137C/-607A haplotypes in the IL-18 gene were over-represented in HIV patients presenting LS. The -137G/-607C haplotype was associated with protection against LS. These results indicate that the -607(C/A) SNP is associated with LS development in HIV-infected patients. (AU)

• Processo FAPESP: 06/58476-7 - Polimorfismo da interleucina 18 e do interferon gama na sindrome da lipodistrofia associada a terapia anti-retroviral em portadores do hiv-1.
• Beneficiário: Luciana Castelar
• Modalidade de apoio: Bolsas no Brasil - Mestrado