Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome

Full text
Author(s):
Castelar, L. [1] ; Silva, M. M. [1] ; Castelli, E. C. [2] ; Deghaide, N. H. S. [2] ; Mendes-Junior, C. T. [3] ; Machado, A. A. [2] ; Donadi, E. A. [2] ; Fernandes, A. P. M. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Coll Nursing Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040902 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: TISSUE ANTIGENS; v. 76, n. 2, p. 126-130, AUG 2010.
Web of Science Citations: 13
Abstract

Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions -607(C/A) and -137(C/G) in the promoter region of the interleukin-18 (IL-18) gene and at position +874(T/A) of the interferon-gamma (IFN-gamma) gene are related to the expression of these cytokines. To examine whether IL-18 and IFN-gamma polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)-infected patients presenting LS, 79 HIV-infected without LS, and 133 healthy controls. The -607A allele, -607AA genotype, and -137G/-607A and -137C/-607A haplotypes in the IL-18 gene were over-represented in HIV patients presenting LS. The -137G/-607C haplotype was associated with protection against LS. These results indicate that the -607(C/A) SNP is associated with LS development in HIV-infected patients. (AU)