Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine

Autor(es):Mostrar menos -

Cardoso de Almeida, J. R. ^{[1, 2]} ; Phillips, M. L. ^[1] ; Cerqueira, C. T. ^[2] ; Zilberman, M. ^[2] ; Lobo, D. ^[2] ; Henna, E. ^[2] ; Tavares, H. ^[2] ; Amaro, E. ^[3] ; Gorenstein, C. ^{[4, 5]} ; Gentil, V. ^{[2, 5]} ; Busatto, G. F. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA - USA

^[2] Univ Sao Paulo, Fac Med, Dept Psiquiatria, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Dept Radiol, NIF LIM44, BR-05508 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508 Sao Paulo - Brazil

^[5] FMUSP, Hosp Clin, Lab Invest Med 23, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHOPHARMACOLOGY; v. 24, n. 8, p. 1165-1174, AUG 2010.
• Citações Web of Science: 8

Resumo

Previous functional magnetic resonance imaging (fMRI) studies examined neural activity responses to emotive stimuli in healthy individuals after acute/subacute administration of antidepressants. We now report the effects of repeated use of the antidepressant clomipramine on fMRI data acquired during presentation of emotion-provoking and neutral stimuli on healthy volunteers. A total of 12 volunteers were evaluated with fMRI after receiving low doses of clomipramine for 4 weeks and again after 4 weeks of washout. Fear-, happiness-, anger-provoking and neutral pictures from the International Affective Picture System (IAPS) were used. Data analysis was performed with statistical parametric mapping (P < 0.05). Paired t-test comparisons for each condition between medicated and unmedicated states showed, to negative valence paradigms, decrease in brain activity in the amygdala when participants were medicated. We also demonstrated, across both positive and negative valence paradigms, consistent decreases in brain activity in the medicated state in the anterior cingulate gyrus and insula. This is the first report of modulatory effects of repeated antidepressant use on the central representation of somatic states in response to emotions of both negative and positive valences in healthy individuals. Also, our results corroborate findings of antidepressant-induced temporolimbic activity changes to emotion-provoking stimuli obtained in studies of subjects treated acutely with such agents. (AU)

• Processo FAPESP: 01/00189-9 - Estudo psicológico da regulação emocional a partir dos efeitos de antidepressivos
• Beneficiário: Valentim Gentil Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático