Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hepatogenous photosensitization associated with liver copper accumulation in buffalos

Texto completo
Autor(es):
Minervino, Antonio H. H. [1] ; Barreto Junior, Raimundo A. [1] ; Rodrigues, Frederico A. M. L. [1] ; Ferreira, Rodrigo N. F. [1] ; Reis, Leonardo F. [1] ; Headley, Selwyn A. ; Ortolani, Enrico L. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Coll Vet Med, Dept Clin Sci, BR-05508270 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Research in Veterinary Science; v. 88, n. 3, p. 519-522, JUN 2010.
Citações Web of Science: 5
Resumo

Four 1.5-year-old, male, Murrah buffalos were maintained during eight months without direct solar exposure during a study of copper toxicosis. Four days after solar exposure, all buffalos presented clinical manifestations consistent with acute photosensitization, including anorexia, apathy, loss of body weight, and generalized cutaneous lesions. Gross lesions were characterized by severe erythema, localized edema, fissures, tissue necrosis, gangrene and crust formation with h serous exudation. Liver copper concentration was evaluated, and cutaneous biopsies were taken when clinical signs were evident. The liver copper concentration before solar exposure was increased in all animals. Histopathologic examination of the skin revealed hepatogenous photosensitization characterized by parakeratotic hyperkeratosis, acantholysis, degeneration of squamous epithelial cells, epidermal necrosis with atrophy of sweat glands, and multifocal superficial and deep dermal edema. These findings suggest that asymptomatic accumulation of copper within the liver might have induced hepatic insufficiency thereby resulting in secondary photosensitization when these buffalos were exposed to sunlight. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 05/03204-0 - Estudo comparativo da susceptibilidade de bovinos e bubalinos à intoxicação cúprica acumulativa
Beneficiário:Enrico Lippi Ortolani
Linha de fomento: Auxílio à Pesquisa - Regular