The Impact of Vitamin A Supplementation on the Immune System of Vitamin A-deficient Children

Autor(es)

Paiva, Adriana de Azevedo ^{[1, 2]} ; Rondo, Patricia Helen ; Vaz-de-Lima, Lourdes Rehder ^[3] ; Oliveira, Carmem de Freitas ; Ueda, Mirthes ^[4] ; Goncalves-Carvalho, Cecilia ^[5] ; Reinaldo, Luis Gustavo ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, Sao Paulo - Brazil

^[2] Fed Univ Teresina, Dept Nutr, Piaui - Brazil

^[3] Adolfo Lutz Inst, Immunol Sect, Sao Paulo - Brazil

^[4] Univ Fed Piaui, Dept Nutr, Teresina, Piaui - Brazil

^[5] Univ Fed Campina Grande, Fac Med, Campina Grande, Paraiba - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH; v. 80, n. 3, p. 188-196, JUN 2010.
• Citações Web of Science: 6

Resumo

Background \& Aims: To investigate the effect of vitamin A supplementation on parameters of the immune system of vitamin A-deficient children. Methods: The study was carried out in four phases: 1) determination of serum retinol in 631 children from 36 to 83 months of age; 2) assessment of immunological markers {[}immunoglobulins and complement fractions, immunophenotyping of T and B lymphocytes, and natural killer (NK) cells], blood count, and serum ferritin of 52 vitamin A-deficient children (serum retinol <0.70 mu mol/L); 3) supplementation of the 52 deficient children with 200,000 IU of vitamin A; 4) determination of serum retinol and the immunological parameters 2 months after vitamin A supplementation. Results: Before vitamin A supplementation, 24.0% of the children were anemic and 4.3 %had reduced ferritin concentrations. There was no significant difference between mean values of retinol according to the presence/absence of anemia. The mean values of the humoral and cellular immunological parameters did not show a statistically significant difference before and after supplementation with vitamin A. Children with concomitant hypovitaminosis A and anemia presented a significant increase in absolute CD4 and CD8 T-cell counts after vitamin A supplementation (p < 0.05). Conclusion: Vitamin A had an effect on the recruitment of T and B lymphocytes to the circulation of children with hypovitaminosis A and anemia. (AU)

• Processo FAPESP: 01/07899-1 - O impacto da suplementacao com vitamina a no sistema imunologico de pre-escolares.
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular