Chagas' disease: an update on immune mechanisms and therapeutic strategies

Autor(es)

Boscardin, Silvia Beatriz ^[1] ; Troccoli Torrecilhas, Ana Claudia ^{[1, 2]} ; Manarin, Romina ^[3] ; Revelli, Silvia ^[3] ; Gonzalez Rey, Elena ^[4] ; Tonelli, Renata Rosito ^[5] ; Silber, Ariel Mariano ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil

^[2] Mackenzie Presbeterian Univ, Ctr Biomol Sci & Hlth, Sao Paulo - Brazil

^[3] Natl Univ Rosario, Sch Med Sci, Inst Immunol, Rosario, Santa Fe - Argentina

^[4] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada - Spain

^[5] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; v. 14, n. 6B, p. 1373-1384, JUN 2010.
• Citações Web of Science: 25

Resumo

The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. In the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system. (AU)

• Processo FAPESP: 08/57596-4 - Metabolismo de aminoácidos de Trypanosoma cruzi: alvos putativos para terapia
• Beneficiário: Ariel Mariano Silber
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/08648-9 - Direcionamento de antígenos recombinantes para células dendríticas in vivo: uma nova estratégia para o desenvolvimento de vacinas
• Beneficiário: Silvia Beatriz Boscardin
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores