Gels Containing MMP Inhibitors Prevent Dental Erosion in situ

Autor(es)

Kato, M. T. ^[1] ; Leite, A. L. ^[1] ; Hannas, A. R. ^[1] ; Buzalaf, M. A. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DENTAL RESEARCH; v. 89, n. 5, p. 468-472, MAY 2010.
• Citações Web of Science: 58

Resumo

Matrix metalloproteinase (MMP) inhibition has been shown to reduce dentin caries progression, but its role in dental erosion has not yet been assessed. This study tested the hypothesis that gels containing MMP inhibitors (epigallocatechin gallate-EGCG and chlorhexidine) can prevent dental erosion. Volunteers (n = 10) wore palatal devices containing bovine dentin blocks (n = 10/group) treated for 1 min with EGCG at 10 (EGCG10) or 400 mu M (EGCG400), chlorhexidine at 0.012%, F at 1.23% (NaF), and no vehicle (placebo). Erosion was performed with Coca-Cola (R) (5 min) 4X/day during 5 days. The wear, assessed by profilometry (mean +/- SD, mu m), was significantly reduced by the gels containing MMP inhibitors (0.05 +/- 0.02(a), 0.04 +/- 0.02(a), and 0.05 +/- 0.02(a) for EGCG10, EGCG400, and chlorhexidine, respectively) when compared with NaF (0.79 +/- 0.35(b)) and placebo gels (1.77 +/- 0.35(b)) (Friedman and Dunn's tests, p < 0.01). The use of gels delivering MMP inhibitors was shown to prevent erosion and opens a new perspective for protection against dental erosion. (AU)

• Processo FAPESP: 07/04209-0 - Avaliação do efeito do chá verde, inibidor natural das metaloproteinases de matriz, sobre a erosão da dentina associada ou não à abrasão: um estudo in situ
• Beneficiário: Melissa Thiemi Kato
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 07/08389-3 - Avaliação do efeito de inibidores de metaloproteinases de matriz sobre a erosão dentária: estudos in situ / ex vivo
• Beneficiário: Marília Afonso Rabelo Buzalaf
• Modalidade de apoio: Auxílio à Pesquisa - Regular