In vivo anti-angiogenic effects further support the promise of the antineoplasic activity of methyl jasmonate

Autor(es)

Pereira Lopes, J. E. F. ^[1] ; Barbosa, M. R. ^[1] ; Stella, C. N. ^[1] ; Santos, W. A. ^[1] ; Pereira, E. M. ^[1] ; Nogueira-Neto, J. ^[2] ; Augusto, E. M. ^[1] ; Silva, V, L. ^[3] ; Smaili, S. S. ^[4] ; Gomes, L. F. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin & Toxicol, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Biol, BR-09972270 Diadema, SP - Brazil

^[3] Silva, L., V, Univ Sao Paulo, Dept Anal Clin & Toxicol, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Farmacol, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Biology; v. 70, n. 2, p. 443-449, MAY 2010.
• Citações Web of Science: 7

Resumo

Molecular plant components have long been aimed at the angiogenesis and anti-angiogenesis pathways, and have been tested as sources for antineoplasic drugs with promising success. The present work deals with the anti-angiogenic effects of Methyl Jasmonate. Jasmonate derivatives were demonstrated to selectively damage the mitochondria of cancer cells. In vitro, 1-10 mM Methyl Jasmonate induced the cell death of the human umbilical vein endothelial cells (HUVECT) and the Murine melanoma cells (B16F10), while micromolar concentrations were ineffective. In vivo, comparable concentrations were toxic and reduced the vessel density of the Chorioallantoic Membrane of the Chicken Embryo (CAM). However. 1-10 mu M concentrations produced a complex effect. There was increased capillary budding, but the new vessels were leakier and less organised than corresponding controls. It is suggested that not only direct toxicity, but also the drug effects upon angiogenesis are relevant to the antineoplasic effects of Methyl Jasmonate. (AU)

• Processo FAPESP: 07/57728-5 - Mecanismos de ação da beta 2-glicoproteína I sobre fagócitos humanos
• Beneficiário: Lígia Ferreira Gomes
• Modalidade de apoio: Auxílio à Pesquisa - Regular