Polybioside, a Neuroactive Compound from the Venom of the Social Wasp Polybia paulista

Autor(es)

Saidemberg, Daniel M. ^[1] ; da Silva-Filho, Luiz C. ^[2] ; Cesar Tognoli, Lilian M. M. ^[1] ; Tormena, Claudio F. ^[3] ; Palma, Mario S. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Inst Biosci, Lab Struct Biol & Zoochem, Dept Biol CEIS, BR-13506900 Rio Claro, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Dept Chem, BR-17033360 Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Inst Chem, UNICAMP, BR-13084971 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 73, n. 4, p. 527-531, APR 2010.
• Citações Web of Science: 7

Resumo

Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied. (AU)

• Processo FAPESP: 04/07942-2 - A bioprospecção da fauna de artrópodes do estado de São Paulo pela procura de compostos-líderes para o desenvolvimento racional de novos fármacos e pesticidas seletivos
• Beneficiário: Mario Sergio Palma
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular