Genetic Diversity on the Integrase Region of the pol Gene among HIV Type 1-Infected Patients Naive for Integrase Inhibitors in Sao Paulo City, Brazil

Autor(es)

Arruda, Lia Barbara ^{[1, 2]} ; Fonseca, Luiz Augusto M. ^[3] ; Duarte, Alberto J. S. ^{[4, 2]} ; Casseb, Jorge ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil

^[2] FMUSP, Lab Med Invest Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AIDS Research and Human Retroviruses; v. 26, n. 1, p. 105-107, JAN 2010.
• Citações Web of Science: 9

Resumo

The presence of mutations associated with integrase inhibitor (INI) resistance among INI-naive patients may play an important clinical role in the use of those drugs Samples from 76 HIV-1-infected subjects naive to INIs were submitted to direct sequencing. No differences were found between naive (25%) subjects and subjects on HAART (75%). No primary mutation associated with raltegravir or elvitegravir resistance was found. However, 78% of sequences showed at least one accessory mutation associated with resistance. The analysis of the 76 IN sequences showed a high polymorphic level on this region among Brazilian HIV-1-infected subjects, including a high prevalence of aa substitutions related to INI resistance. The impact of these findings remains unclear and further studies are necessary to address these questions. (AU)

• Processo FAPESP: 08/51265-6 - Determinação do tropismo do HIV-1 pelos co-receptores CCR5 e CXCR4 pelo uso de ferramentas de bioinformática
• Beneficiário: Liã Bárbara Arruda
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/58138-0 - Aplicação de instrumentos de bioinformática na avaliação de novas classes de antiretrovirais: antagonistas de CCR5 e inibidores de integrase
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular