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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Diversity on the Integrase Region of the pol Gene among HIV Type 1-Infected Patients Naive for Integrase Inhibitors in Sao Paulo City, Brazil

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Author(s):
Arruda, Lia Barbara [1, 2] ; Fonseca, Luiz Augusto M. [3] ; Duarte, Alberto J. S. [4, 2] ; Casseb, Jorge [1, 2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[2] FMUSP, Lab Med Invest Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: AIDS Research and Human Retroviruses; v. 26, n. 1, p. 105-107, JAN 2010.
Web of Science Citations: 9
Abstract

The presence of mutations associated with integrase inhibitor (INI) resistance among INI-naive patients may play an important clinical role in the use of those drugs Samples from 76 HIV-1-infected subjects naive to INIs were submitted to direct sequencing. No differences were found between naive (25%) subjects and subjects on HAART (75%). No primary mutation associated with raltegravir or elvitegravir resistance was found. However, 78% of sequences showed at least one accessory mutation associated with resistance. The analysis of the 76 IN sequences showed a high polymorphic level on this region among Brazilian HIV-1-infected subjects, including a high prevalence of aa substitutions related to INI resistance. The impact of these findings remains unclear and further studies are necessary to address these questions. (AU)