Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline

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Scalco, Andreia Zavaloni ^[1] ; Pinto Brandao Rondon, Maria Urbana ^[2] ; Trombetta, Ivani Credidio ^[2] ; Laterza, Mateus Camaroti ^[2] ; Carvalho Serro Azul, Joao Batista Costa ^[2] ; Pullenayegum, Eleanor Maria ^[3] ; Scalco, Monica Zavaloni ^[4] ; Kuniyoshi, Fatima Helena Sert ^[5] ; Wajngarten, Mauricio ^[2] ; Negrao, Carlos Eduardo ^[2] ; Lotufo-Neto, Francisco ^{[6, 7]}

Afiliação do(s) autor(es)

^[1] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON - Canada

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[3] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4L8 - Canada

^[4] Univ Toronto, Dept Psychiat, Toronto, ON - Canada

^[5] Mayo Clin, Rochester, MN - USA

^[6] Univ Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Inst Psychiat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Hypertension; v. 27, n. 12, p. 2429-2436, DEC 2009.
• Citações Web of Science: 33

Resumo

Background Sympathetic hyperactivity is one of the mechanisms involved in the increased cardiovascular risk associated with depression, and there is evidence that antidepressants decrease sympathetic activity. Objectives We tested the following two hypotheses: patients with major depressive disorder with high scores of depressive symptoms (HMDD) have augmented muscle sympathetic nervous system activity (MSNA) at rest and during mental stress compared with patients with major depressive disorder with low scores of depressive symptoms (LMDD) and controls; sertraline decreases MSNA in depressed patients. Methods Ten HMDD, nine LMDD and 11 body weight-matched controls were studied. MSNA was directly measured from the peroneal nerve using microneurography for 3 min at rest and 4 min during the Stroop color word test. For the LMDD and HMDD groups, the tests were repeated after treatment with sertraline (103.3 +/- 40 mg). Results Resting MSNA was significantly higher in the HMDD {[}29.1 bursts/min (SE 2.9)] compared with LMDD {[}19.9 (1.6)] and controls {[}22.2 (2.0)] groups (P=0.026 and 0.046, respectively). There was a significant positive correlation between resting MSNA and severity of depression. MSNA increased significantly and similarly during stress in all the studied groups. Sertraline significantly decreased resting MSNA in the LMDD group and MSNA during mental stress in LMDD and HMDD groups. Sertraline significantly decreased resting heart rate and heart rate response to mental stress in the HMDD group. Conclusion Moderate-to-severe depression is associated with increased MSNA. Sertraline treatment reduces MSNA at rest and during mental challenge in depressed patients, which may have prognostic implications in this group. J Hypertens 27:2429-2436 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

• Processo FAPESP: 02/02419-4 - Alteracoes de sistema nervoso autonomico (sna) em pacientes deprimidos antes e apos tratamento com antidepressivo.
• Beneficiário: João Batista Costa Carvalho de Serro-Azul
• Modalidade de apoio: Auxílio à Pesquisa - Regular