Schistosomicidal Evaluation of Zanthoxylum naranjillo and its Isolated Compounds against Schistosoma mansoni Adult Worms

Autor(es)

Braguine, Caio G. ^[1] ; Costa, Eveline S. ^[1] ; Magalhaes, Lizandra G. ^[2] ; Rodrigues, Vanderlei ^[2] ; da Silva Filho, Ademar A. ^[2] ; Bastos, Jairo K. ^[3] ; Silva, Marcio L. A. ^[1] ; Cunha, Wilson R. ^[1] ; Januario, Ana H. ^[1] ; Pauletti, Patricia M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, BR-14404600 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040903 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES; v. 64, n. 11-12, p. 793-797, NOV-DEC 2009.
• Citações Web of Science: 10

Resumo

Chemical investigation of the EtOAc fraction (EF) obtained from the ethanolic extract of Zanthoxylum naranjillo (Rutaceae) leaves (EE) by preparative HPLC resulted in the isolation of protocatechuic acid (1), gallic acid (2), p-hydroxybenzoic acid (3), and 5-O-caffeoylshikimic acid (4). This is the first time that the presence of compounds 1-4 in Z. naranjillo has been reported. Compounds 1-4, the EE, and EF were tested in vitro against Schistosoma mansoni adult worms. The results showed that the S. mansoni daily egg production decreased by 29.8%, 13.5% 28.4%, 17.7%, 16.3%, and 6.4%, respectively. Compounds 1 and 3 were also able to separate adult worm pairs into male and female. This activity may be correlated with the reduction in egg production, since 1 and 3 showed better inhibitory properties compared with 2 and 4. (AU)

• Processo FAPESP: 06/60132-4 - Investigação das atividades esquistossomicida, tripanocida e leishmanicida de lignanas e neolignanas obtidas por acoplamento oxidativo in vitro de fenilpropanóides
• Beneficiário: Ademar Alves da Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/01268-9 - Estudo fitoquímico e avaliação das atividades antimalárica, antimicrobiana e de inibição da enzima acetilcolinesterase de espécies nativas do cerrado do estado de São Paulo
• Beneficiário: Ana Helena Januário
• Modalidade de apoio: Auxílio à Pesquisa - Regular