Potential agents to control enamel caries-like lesions

Autor(es)

Rehder Neto, F. C. ^[1] ; Maeda, F. A. ^[1] ; Turssi, C. P. ^[2] ; Serra, M. C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Restorat Dent, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Uberaba, Sch Dent, Lab Biomat Res, Uberaba, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Dentistry; v. 37, n. 10, p. 786-790, OCT 2009.
• Citações Web of Science: 19

Resumo

Objectives: To assess whether pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium sodium phosphosilicate (CSP) control artificial caries lesion progression. Methods: Enamel slabs of bovine teeth were embedded in polyester resin and had their enamel surfaces serially polished, and tested for surface microhardness (SMH, 25 g, 5 s). Incipient caries-like lesions were pre-formed and specimens were evaluated by microhardness test (SMH(post-lesion)) and randomly assigned to five treatment groups (n = 15): (1) regular dentifrice (RE, 1,100 ppm F); (2) dentifrice with calcium sodium phosphosilicate (CSP); (3) amorphous calcium phosphate stabilized by casein phosphopeptide (CPP-ACP); (4) CPP-ACP with 900 ppm F (CPP-ACP + F) and (5) control group-unexposed to any remineralizing agent. Treatments were applied five times, after the de-remineralization period in the cariogenic challenges. Post-treatments SMH measurements were conducted (SMH(post-treatment)). Results: ANOVA was applied for data evaluation and revealed a significant difference among the treatments (p = 0.0161). Tukey's test was conducted and the percentage of mineral loss was calculated. Specimens exposed to CSP (7.1%), RE (6.7%) and CPP-ACP + F (3.8%) showed lower mineral loss than those that in the control group (-11.0%). CPP-ACP group (3.2%) differed from the control, CSP and RE groups. Conclusions: Depending on the agent used, a remineralizing effect may be expected, which reflects in caries lesions progression. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 06/05277-7 - Avaliação da perda do conteúdo mineral em lesões artificiais de cárie através de análise por microscopia de luz polarizada em relação à microdureza
• Beneficiário: Francisco Carlos Rehder Neto
• Modalidade de apoio: Bolsas no Brasil - Mestrado